炎症负担指数是接受治疗治疗的食道癌症患者的独立预后因素
Toru Aoyama1, Yukio Maezawa2, Itaru Hashimoto3
1Department of Surgery, Yokohama City University, Yokohama, Japan t-aoyama@lilac.plala.or.jp.
In vivo (Athens, Greece)
|October 30, 2024
概括
炎症负担指数 (IBI) 是接受治疗治疗的食道癌症 (EC) 患者结果的重要预测指标. 较高的IBI得分与较差的整体存活率和无复发存活率相关,突出显示了其预后价值.
科学领域:
- 在瘤学瘤学.
- 生物标志物 生物标志物
- 炎症研究的研究.
背景情况:
- 食道癌 (EC) 是一个重大的全球健康挑战.
- 确定可靠的预后生物标志物对于有效的EC治疗和管理至关重要.
- 炎症负担指数 (IBI) 已成为系统性炎症的潜在指标.
研究的目的:
- 在接受治疗治疗的食道癌 (EC) 患者中研究炎症负担指数 (IBI) 的预后影响.
- 评估IBI作为预测EC患者整体存活率 (OS) 和无复发存活率 (RFS) 的潜在生物标志物.
主要方法:
- 从2005年至2020年期间接受治疗切除的180名EC患者的医疗记录的回顾性分析.
- 使用公式计算IBI得分:C反应蛋白水平 × 中性粒细胞与淋巴细胞的比率.
- 多变量分析以评估IBI作为OS和RFS的预后因素的重要性.
主要成果:
- 与IBI得分较低 (72.9%和63.4%;p<0.001) 的患者相比,IBI得分较高的患者表现出明显较低的3年和5年的OS率 (38.2%和32.5%).
- IBI是OS (HR=2.372) 和RFS (HR=2.484;p<0.001) 的一个显著的独立预后因素.
- 与低IBI相比,高IBI与淋巴结复发率 (46.0%与26.2%) 和血液复发率 (52.0%与18.5%) 的增加有关.
结论:
- 炎症负担指数 (IBI) 显著影响食道癌患者的短期和长期瘤结果.
- IBI显示出作为一个有价值的预后生物标志物的潜力,用于指导EC的治疗和管理策略.
- 需要进一步的前性研究来验证IBI在EC临床实践中的作用.
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