用奥里塔万辛治疗复发的抗万科明素Enterococcus faecium细菌病的管理:一个病例报告
Samuel Jalali1, Hetanshi Bhatt2, Keval Thakkar2
1Department of Internal and Hospital Medicine, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, U.S.A.; Samuel.Jalali@moffitt.org.
In vivo (Athens, Greece)
|October 30, 2024
概括
这项案例研究突出了成功的非标签使用奥里塔万来治疗复发的抗万科胺素的Enterococcus faecium bacteremia在患有血液性恶性瘤的患者. 奥里塔万辛为对抗多药性VREf感染提供了潜在的新选择.
科学领域:
- 传染性疾病 传染性疾病
- 血液学 血液学 血液学
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗万科胺素的Enterococcus (VRE) 感染存在重大风险,特别是在接受干细胞移植的血液性恶性瘤患者中.
- 在这种高风险人群中,VRE感染的死亡率可以在40-100%之间.
- 对线索利德和达普托米辛的新兴耐药性使VRE感染的治疗复杂化.
研究的目的:
- 报告一例罕见的成功救援治疗多药耐药VRE细菌病的罕见病例.
- 在复杂的患者场景中评估奥里塔万的非标签性使用.
主要方法:
- 一个病例报告,一个48岁的男性患有血液性恶性瘤和干细胞移植后的移植失败.
- 治疗复发的抗万科胺素抗性Enterococcus faecium (VREf) 细菌症,该细菌症对标准治疗不耐药.
- 标签之外的oritavancin作为救援疗法在记录下来对达普托米辛和线索立德的耐药性后进行注射.
主要成果:
- 患者经历了复发的VREf细菌病尽管多次干预.
- 经过非标签使用oritavancin后,血液培养物被清除.
- 这代表了一名耐火性VREf细菌病患者的成功结局.
结论:
- 在免疫功能低下的患者中,成功使用非标签的奥里塔万辛治疗复发性多药耐药VREf细菌病.
- 突出了oritavancin作为救援疗法选择的潜力.
- 强调需要提高对ORITAVANCIN对VREf感染的认识,因为对一线药物耐药性日益增加.
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