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通过PSMA PET/CT和多参数MRI检测前列腺癌的临床,病理和成像变量

Ida Sonni^1,2, Adam B Weiner^3,4, Sahith Doddipalli⁵

¹Department of Radiological Sciences, UCLA, Los Angeles, California; isonni@mednet.ucla.edu.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine

|October 30, 2024

概括

前列腺特异性膜抗原 (PSMA) PET/CT检测出比多参数核磁共振 (mpMRI) 更具有临床意义的前列腺癌 (PCa),特别是较小的瘤. 这两种成像方法都擅长识别攻击性PCa,有助于术前评估.

科学领域:

在瘤学瘤学.
放射学放射学是一门学科.
核医学是一种核医学.

背景情况:

多参数MRI (mpMRI) 和前列腺特异性膜抗原 (PSMA) PET/CT是前列腺癌 (PCa) 手术前评估的关键.
这些成像模式是互补的,但它们在检测临床显著PCa (csPCa) 的性能需要进一步描述.

研究的目的:

为了比较PSMA PET/CT和mpMRI对csPCa的检测率.
描述PCa瘤仅通过PSMA PET/CT检测,而通过mpMRI没有检测到.

主要方法:

在进行激进前列腺切除术之前,对100名接受PSMA PET/CT和mpMRI治疗的患者进行了回顾性分析.
由核医学医生和放射科医生进行独立的损伤轮,随后进行共识审查.
由生殖尿路病理学家对132个csPCa瘤进行病理学审查,以评估成像-病理相关性.

主要成果:

在病变水平 (87% vs. 80%) 和患者水平 (98% vs. 94%) 上,PSMA PET/CT表现出比mpMRI更高的灵敏度.
通过这两种方法检测到的瘤都比较大,并且具有更高等级的组.
PSMA PET/CT检测到mpMRI遗漏的较小的csPCa;像cribriform模式和导管内癌症这样的侵略性特征被两者都检测得很好.

结论:

与mpMRI相比,PSMA PET/CT可以更好地检测csPCa,特别是较小的病变.
这两种方法都能有效地识别高度瘤,这表明联合使用完善了前术前前列腺癌评估.

关键词:

在PSMA PET/CT中使用.多参数核磁共振成像 (MRI)前列腺癌是前列腺癌.前列腺癌的分期:前列腺癌的分期整个山上的病理学.

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