致死性败血栓休克 由于Dolosigranulum pigrum Bacteremia:一个案例报告
Sachiko Hakoda1, Akira Ishiwata1,2, Ryo Shimada3
1Tone Chuo Hospital, Japan.
Japanese journal of infectious diseases
|October 30, 2024
概括
一种罕见的Dolosigranulum pigrum细菌病导致了一名患有神经omyelitis optica光谱障碍的老年患者致命的败血症休克. 这一案例凸显了这种通常无害的细菌感染的潜在严重性.
科学领域:
- 微生物学 微生物学
- 神经学 神经学
- 传染性疾病 传染性疾病
背景情况:
- 神经omyelitis optica光谱障碍 (NMOSD) 是一种罕见的自身免疫性疾病,影响中枢神经系统.
- Dolosigranulum pigrum是一种通常在上呼吸道中发现的细菌,很少涉及人类感染.
- 由D. pigrum引起的感染可能是严重的,特别是在免疫受损的个体.
研究的目的:
- 报告一个患有神经髓炎光学谱系障碍的患者的Dolosigranulum pigrum bacteremia致命病例.
- 使用分子方法来鉴定D. pigrum分离物的特征.
- 讨论D. pigrum的潜在致病性.
主要方法:
- 一个77岁的日本妇女患有NMOSD的案例报告.
- 致病细菌菌株的16S rRNA测序和murJ基因分析.
- 使用邻居连接方法和弗洛雷斯拉莫斯分类的家族遗传学分析.
主要成果:
- 患者出现了急性败血性休克和意识改变.
- 病原体被确定为Dolosigranulum pigrum. 这是一种.
- 遗传学分析将这种分离物置于Clade C3.
结论:
- Dolosigranulum pigrum可以引起严重的,危及生命的感染,包括败血症休克.
- 这一案例强调了在重症患者中考虑罕见病原体的重要性,即使是那些患有潜在疾病的患者.
- 需要进一步的研究来了解D. pigrum感染的致病性和临床谱.
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