短期运动可以抵消加速衰老对小鼠身体表现和肝脏健康的影响
Ana P Pinto1, Vitor R Muñoz1, Maria Eduarda A Tavares2,3
1School of Physical Education and Sport of Ribeirão Preto, University of São Paulo (USP), São Paulo, Brazil.
Clinical and experimental pharmacology & physiology
|October 30, 2024
概括
联合炼通过改善线粒体功能和减少脂肪积累,有利于衰老的肝脏. 这种干预措施显示出增强老年人群肝脏健康和寿命的潜力.
科学领域:
- 老年学和运动生理学
- 肝病学和代谢健康
背景情况:
- 肝脏衰老会对生理学,线粒体功能和昼夜调节产生负面影响,导致代谢功能障碍.
- 有限的研究存在于联合炼对老化的肝脏的影响.
研究的目的:
- 评估联合运动对老化加速小鼠模型 (SAMP8和SAMR1) 肝脏代谢,昼夜节律和线粒体功能的影响.
- 为了研究衰老的肝脏中运动诱导的分子适应.
主要方法:
- 使用了老化加速小鼠易患8 (SAMP8) 和老化加速小鼠抵抗1 (SAMR1) 的小鼠.
- 采用了组织学,RT-qPCR,免疫阻塞,转录组分析和AML12肝细胞研究.
- 在联合运动干预之前和之后评估肝脏生理学,线粒体功能和昼夜标志物.
主要成果:
- 久坐不动的SAMP8小鼠显示肌肉强度降低,线粒体复合体I降低,脂质滴滴增加.
- 在SAMP8小鼠中,联合炼改善了肌肉力量,上调了线粒体复合体 (CIII,CIV,CV),并增加了肝脏Bmal1mRNA.
- 运动降低了老年小鼠的高脂含量,表明肝脏受益,但没有改善有氧能力.
结论:
- 结合力量和耐力运动可以减轻与年龄相关的肝功能障碍,并改善老年小鼠的线粒体功能.
- 分子适应表明运动可以增强肝脏代谢功能和细胞寿命.
- 运动干预措施可能提供一种可行的策略,用于对抗老年人群中与年龄相关的肝病.
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