治疗COVID-19相关的嗅觉功能障碍:系统性审查
Sabrina Bischoff1,2, Mathilde Moyaert1, Marnick Clijsters3
1Department of Otorhinolaryngology, Head and Neck Surgery, University Hospitals Leuven, Leuven, Belgium.
Current allergy and asthma reports
|October 31, 2024
概括
富含血小板血 (PRP) 和胆剂在治疗COVID-19相关的嗅觉功能障碍方面显示出有前途. 发现嗅觉训练和皮质类固醇在改善嗅觉功能得分方面无效.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- COVID-19经常导致嗅觉功能障碍,影响生活质量.
- 迫切需要有效的治疗COVID后的嗅觉丧失.
- 目前的治疗策略缺乏可靠的证据.
研究的目的:
- 系统地审查COVID-19相关的嗅觉功能障碍的治疗方法.
- 为临床应用提供基于证据的建议.
- 分析各种治疗方法的疗效.
主要方法:
- 对36项随机对照试验和非随机研究的系统综述 (2020年1月 - 2023年11月).
- 对9个治疗组的分析:嗅觉训练,皮质类固醇,PRP,合剂,维生素补充剂,胰岛素, gabapentin,脑溶解剂.
- 主要结果:通过客观测试来改变嗅觉功能得分 (OFS).
主要成果:
- 丰富血小板血 (PRP) 和胆剂显著改善了OFS.
- 嗅觉训练在改善OFS方面没有显著的有效性.
- 皮质类固醇也在COVID-19嗅觉功能障碍方面表现出有限的疗效.
结论:
- PRP和化剂代表了COVID-19嗅觉功能障碍的潜在治疗选择.
- 根据目前的证据,不建议使用嗅觉训练和皮质类固醇.
- 需要进一步的研究来建立最佳的治疗方案.
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