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微量元素暴露会影响体外受精胚胎移植的结果,这是中国北部的一项队列研究

Ying Li¹, Lin Liu², Jun Zhang¹

¹Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, No. 251 Yaojiayuan Road, Chaoyang District, Beijing, 100026, China.

Journal of assisted reproduction and genetics

|October 31, 2024

概括

微量元素暴露对体外受精胚胎移植 (IVF-ET) 成功的影响. 较高的铜 (Cu), (Mn), (Zn) 和 (Ge) 含量与更好的IVF-ET结果有关,而 (Al) 和 (Pb) 与较差的结果有关.

科学领域:

环境暴露和生殖健康.
人类生物样本中的微量元素分析.
在体外受精 (IVF) 和胚胎移植 (ET) 的结果.

背景情况:

城市化和工业化的增加导致人类对微量元素的暴露越来越大.
微量元素在各种生物过程中起着至关重要的作用,可能会影响生殖功能.

研究的目的:

调查微量元素含量与体外受精胚胎移植 (IVF-ET) 结果之间的关联.
为了确定特定的微量元素,这些微量元素可能会影响接受IVF-ET的妇女的生育和怀孕率.

主要方法:

血清和卵泡液 (FF) 样本从接受IVF-ET的181名女性中收集.
微量元素度使用诱导合的等离子体质谱学量化.
统计分析检查了微量元素含量与IVF-ET结果 (受精,胚胎质量,临床怀孕) 之间的关系.

主要成果:

与FF相比,在28种微量元素中,25种的血清度较高.
在正常受精和FF铜 (Cu) 和 (Mn) 水平之间发现了积极的关联.
高质量的胚胎与血清中的Cu和FF以及血清中的 (Zn) 有关. 临床怀孕与血清 (Ge) 有正相关,与血清 (Al) 和 (Pb) 有负相关.

结论:

试管婴儿-ET结果受到特定微量元素的显著影响,其中Cu,Mn,Zn和Ge具有有益的关联.
血清中Al和Pb水平升高与IVF-ET不良结果有关.
管理对这些关键微量元素的暴露对于优化IVF-ET成功率至关重要.

关键词:

临床怀孕临床怀孕高质量的胚胎.在体外受精胚胎转移胚胎转移.不孕不育不孕不育不孕不育微量元素中的微量元素.

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