高参数蛋白质地图揭示了早期发育的人类肺部的空间组织
Sanem Sariyar1,2, Alexandros Sountoulidis1,3, Jan Niklas Hansen1,2,4
1Science for Life Laboratory, Solna, Sweden.
Nature communications
|October 31, 2024
概括
这项研究绘制了怀孕早期人类发育中的肺部蛋白质组织的地图. 它揭示了用于呼吸系统健康研究的细胞类型,免疫模式和空间安排.
科学领域:
- 发展生物学 发展生物学
- 人类解剖学 人类解剖学
- 细胞生物学 细胞生物学
背景情况:
- 了解人类肺部发育对于呼吸系统健康至关重要.
- 目前的知识严重依赖于动物模型和转录组数据.
- 缺乏早期人类肺部发育的详细蛋白质水平地图.
研究的目的:
- 在怀孕的第一季度,描述人类发育中的肺部蛋白质水平的时空组织.
- 创建一个关于早期人类肺部细胞类型组成和空间模式的全面资源.
- 提供有关呼吸系统健康和疾病发育起源的见解.
主要方法:
- 使用高参数组织成像与30倍体抗体面板.
- 在受孕后6至13周分析了人类肺部样本.
- 在人类发育细胞图谱 (HDCA) 计划中,在五个发育时间点中生成了超过200万个细胞的蛋白质表达数据.
主要成果:
- 详细描述了正在发育的人类肺部的空间分辨的细胞类型组成.
- 在肺部早期发育过程中确定了增殖状态和免疫细胞模式.
- 描述了空间布局特征及其时间演变.
结论:
- 这项研究提供了一个广泛的,单细胞解决,蛋白质水平检查人类发育中的肺部.
- 产生的资源为人类肺部器官生成的早期阶段提供了新的见解.
- 这项工作作为未来研究人类呼吸道疾病发育基础的基础.
相关概念视频
01:17Gross Anatomy of the Lungs
The lungs are a pair of vital organs connected to the trachea via the left and right bronchi. The base of these organs meets the dome-shaped muscle known as the diaphragm. Encased by the pleurae, the lungs contact the mediastinum. The right lung is shorter yet wider, and has a larger volume than the left lung. The left lung has an indentation known as the cardiac notch. The superior region of the lungs is referred to as the apex, whereas the base is the lower region near the diaphragm. The...
01:29Anatomy of Respiratory System I: Upper Respiratory Tract
The upper respiratory tract plays a vital role in the respiratory system, comprising several structures that facilitate air intake and prepare air for the lungs. It also serves as the first line of defense against pathogens and particles. This tract includes the nose and nasal cavity, the oral cavity, the paranasal sinuses, and the pharynx, each with specific functions and features.
Nose and nasal cavity
The nose and nasal cavity represent the main external openings of the respiratory tract.
Nose and nasal cavity
The nose and nasal cavity represent the main external openings of the respiratory tract.
01:31Anatomy of Respiratory System II: Lower Respiratory Tract
The lower respiratory tract is anatomically composed of several vital structures, including the larynx, trachea, bronchial tree, alveoli, lungs, and pleurae. Each component has a specific function, and all are intricately connected to ensure efficient respiration.
The Larynx
It is located between the pharynx and the trachea, acts as a passageway for air, and hosts several critical structures, such as the epiglottis, vocal cords, and glottis. The epiglottis acts as a gateway, guiding food to the...
The Larynx
It is located between the pharynx and the trachea, acts as a passageway for air, and hosts several critical structures, such as the epiglottis, vocal cords, and glottis. The epiglottis acts as a gateway, guiding food to the...