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Updated: Jun 9, 2025

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A Model to Simulate Clinically Relevant Hypoxia in Humans
Published on: December 22, 2016
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月经周期不会影响低氧呼吸反应和急性山病预测
Tom Citherlet1, Antoine Raberin2, Giorgio Manferdelli2
1Institute of Sport Sciences, University of Lausanne, 1015, Lausanne, Switzerland. Tom.Citherlet@unil.ch.
Scientific reports
|October 31, 2024
概括
卵巢激素不会影响低氧呼吸反应 (HVR) 或预测急性山病 (AMS). 在女性的月经周期各阶段,HVR和大脑氧化率保持一致.
科学领域:
- 生理学 生理学 生理学
- 高度医学 高度医学
- 妇女健康 妇女健康
背景情况:
- 低氧呼吸反应 (HVR) 对于适应高海拔地区至关重要,可以预测急性山病 (AMS).
- 周期性卵巢激素波动 (雌激素和孕) 对HVR和AMS易感性的影响尚不清楚.
研究的目的:
- 研究月经周期中卵巢激素的变化如何影响HVR.
- 确定HVR是否可以预测AMS,以及其预测准确度是否因月经阶段而异.
主要方法:
- 十三名妇女在早期的卵泡,晚期的卵泡和中期的卵泡阶段接受了诺莫巴里克缺氧测试 (气呼吸).
- 测量包括HVR,通风,氧和,大脑氧化,氧化应激和激素水平.
- 在模拟高空暴露 (3375米14小时) 后评估了AMS症状.
主要成果:
- 在月经周期各阶段,没有发现HVR,通风或脑氧化的显著差异.
- 这些生理参数和氧化应激标志物在患有AMS的女性和没有患有AMS的女性之间没有差异.
- 无论月经周期阶段如何,HVR并不能预测AMS.
结论:
- 呼吸系统和大脑对缺氧的氧化反应在整个月经周期中是一致的.
- 高频视频和相关的生理标志物不能区分易患AMS的个体.
- 卵巢激素的变化似乎不会影响HVR或其对AMS的预测能力.
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