SARS-CoV-2心血管症状的后急性后果与影响心肌细胞功能的微量细胞因子有关
Jane E Sinclair1, Courtney Vedelago2, Feargal J Ryan3,4
1School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Queensland, Australia.
Nature microbiology
|October 31, 2024
概括
COVID-19心血管症状 (PASC-CVS) 的后急性后果与慢性炎症有关. 纳米技术在PASC-CVS患者中检测到促炎细胞因子,影响心脏细胞功能,并表明炎症在长期COVID心血管问题中的作用.
科学领域:
- 免疫学 免疫学 免疫学
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
背景情况:
- 全球超过6500万人经历了COVID-19 (PASC) 后急性后果.
- 很大一部分PASC患者会出现心血管症状 (PASC-CVS),包括胸痛和心.
- PASC-CVS的潜在机制,特别是在持续病例 (>1年) 中,需要进一步阐明.
研究的目的:
- 研究慢性炎症在PASC-CVS.的发展和持续性中的作用.
- 确定与PASC-CVS相关的特定炎症生物标志物.
- 评估已识别的炎症标志物对心脏细胞的功能影响.
主要方法:
- 血液样本从三个队列中收集:康复的COVID-19个体,长期PASC-CVS的个体和SARS-CoV-2负面对照.
- 血中微量水平的促炎细胞因子被使用纳米技术在感染后18个月量化.
- 评估了血细胞因子对人类初级心肌细胞的功能影响.
- 血蛋白质组学被用来分析补充蛋白和凝固蛋白水平.
主要成果:
- 与对照组相比,患有PASC-CVS的个体表现出明显的炎症血液特征.
- 在PASC-CVS患者的血中检测到微量促炎细胞因子,感染后持续18个月.
- 这些细胞因子显然影响了人类初级心肌细胞的功能.
- 在PASC-CVS患者的血中发现了补充蛋白和凝血蛋白的升高水平.
结论:
- 慢性炎症在COVID-19心血管症状的后急性病理生理学中起着重要作用.
- 检测到的促炎细胞因子和改变的补充/凝血通路代表了PASC-CVS的关键贡献者.
- 这些发现强调了在管理长期COVID心血管并发症方面需要有针对性的抗炎策略.
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