在患有慢性鼻炎和黄金葡萄球菌肠毒素阳性的患者中分析嗅觉功能
Minheon Kim1,2, Hee Sung Chae1, Dong Hwan Kwon1,2
1Department of Otorhinolaryngology-Head and Neck Surgery, Yonsei University Wonju College of Medicine, Ilsan-ro 20, Wonju, Republic of Korea.
Scientific reports
|October 31, 2024
概括
患有慢性鼻炎 (CRS) 的患者,特别是那些患有鼻息肉 (CRSwNP) 的患者,表现出较高的黄 Staphylococcus enterotoxin (SEA/SEB) 敏感性和受损的嗅觉功能. 这表明CRS患者的肠毒素敏感性和嗅觉障碍之间存在联系.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 免疫学 免疫学 免疫学
- 神经科学是一个神经科学.
背景情况:
- 慢性鼻炎 (CRS) 是一种常见的疾病,影响鼻腔和鼻.
- 鼻息肉 (CRSwNP) 与特定的免疫反应有关,可能会影响嗅觉功能.
- 黄金葡萄球菌的肠毒素 (SE) 涉及到炎症状况.
研究的目的:
- 研究CRS患者中黄金葡萄球菌肠毒素A/B (SEA/SEB) 敏感化和嗅觉功能之间的关系.
- 为了在不同的CRS表型 (CRSwNP,CRSsNP) 和健康对照中比较这些因素.
主要方法:
- 对388名受试者 (≥8岁) 的回顾性分析,包括健康对照,CRSsNP和CRSwNP患者.
- 对人口统计,病史,血清IgE对抗SE和吸入过敏原的分析.
- 进行了嗅觉和味觉功能测试,以评估感官感知.
主要成果:
- 与CRSsNP和对照组相比,CRSwNP患者的SEA/SEB阳性明显高于CRSsNP患者.
- 在对照组中,无的患病率为9.7%,在CRSsNP中为22.7%,在CRSwNP中为45.1%.
- 嗅觉功能的得分随着SE血清水平和氨基酸百分比的增加而下降,特别是在CRSwNP中.
结论:
- 在CRSwNP患者中,SEA/SEB敏感性更为普遍.
- CRS,特别是CRSwNP,与显著的嗅觉功能障碍有关.
- SE敏感性和高氨基酸可能会导致CRS的嗅觉恶化.
关键词:
鼻多重体是一种鼻多重体.鼻炎是指鼻炎的一种疾病.过敏化 过敏化嗅觉 (嗅觉) 气味 (嗅觉) 气味 (嗅觉) 气味 (嗅觉) 气味 (嗅觉) 气味 (嗅觉) 气味 (嗅觉) 气味 (嗅觉) 气味 (嗅觉) 气味 (嗅觉)葡萄球菌肠毒素是葡萄球菌肠毒素.更多相关视频
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