血培养负性内心炎是由伊朗的Bartonella quintana引起的
Masoud Azimzadeh1, Mohammad Yousef Alikhani2,3, Alireza Sazmand4
1Department of Microbiology, Hamadan University of Medical Sciences, Hamadan, Iran.
Scientific reports
|October 31, 2024
概括
这项研究调查了伊朗的血培养负内心炎 (BCNE),在一个患者的心脏中发现了巴托内拉昆塔纳DNA. 这标志着巴托内拉在伊朗境内参与BCNE的第一次证据.
科学领域:
- 传染性疾病 传染性疾病
- 心脏病学 心脏病学
- 微生物学 微生物学
背景情况:
- 血液培养阴性内心炎 (BCNE) 存在诊断方面的挑战.
- 延迟诊断BCNE显著影响患者的结果.
- 在BCNE中识别病因因子对于有效治疗至关重要.
研究的目的:
- 调查巴托内拉菌种在伊朗BCNE病例中的作用.
- 在切除的心脏门和BCNE患者的血清样本中检测巴顿氏菌感染.
- 为了确定涉及BCNE.的特定巴托内拉物种.
主要方法:
- 收集了伊朗德黑兰50名BCNE患者的心脏门和血清.
- 使用间接免疫光检测 (IFA) 检测IgG和IgM抗体对抗巴托内拉昆塔纳和B. henselae.
- 使用Sanger测序实时PCR识别Bartonella特异性ssrA基因在心脏膜DNA中.
主要成果:
- 在50名BCNE患者中,有1名表现为巴托内拉IgM阴性,IgG标位高 (>1024).
- 实时PCR检测到Bartonella ssrA基因在一个心脏门样本中.
- 桑格测序证实了阳性样本中巴托内拉昆塔纳的存在,并得到了电子显微镜发现的支持.
结论:
- 这项研究提供了巴托内拉在伊朗血液培养-阴性内心炎中参与的第一个证据.
- 巴托内拉昆塔纳被确定为BCNE病例中的潜在致病原体.
- 建议进行进一步的研究,以探索动物种群中的潜在储库.
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