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Updated: Jul 24, 2026

Limbal Approach-Subretinal Injection of Viral Vectors for Gene Therapy in Mice Retinal Pigment Epithelium
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遗传性玻璃轮氨基粉症与静氨酸Gly83Arg变体,长期研究

Xingwang Chen1,2,3,4, Cheng Xin1,2,3, Gang Su5

  • 1Department of Ophthalmology, Affiliated Hospital of Zunyi Medical University, Zunyi, China.

Eye (London, England)
|October 31, 2024
PubMed
概括

遗传性转基因氨基粉症 (ATTRG83R) 导致视力丧失. 玻璃切除术可以改善视力,但粉样瘤复发和玻璃眼瘤是显著的长期风险,需要仔细跟踪.

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相关概念视频

Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...