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Updated: Jun 9, 2025

Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis
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Bone Marrow Transplantation Procedures in Mice to Study Clonal Hematopoiesis

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在异性造血细胞移植后的克隆动态

Michael Spencer Chapman1,2,3, C Matthias Wilk4, Steffen Boettcher4

  • 1Cancer, Ageing and Somatic Mutation Programme, Wellcome Sanger Institute, Hinxton, UK.

Nature
|October 31, 2024
PubMed
概括

与捐赠者相比,异构造血细胞移植 (HCT) 会导致接受者长期减少干细胞多样性. 这是由于两种选择模式,剪切和生长,夸大了血干细胞与年龄相关的变化.

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