腺素和牛皮风险:在多达90万个人的观察和孟德尔随机化研究
Maria B Nielsen1,2,3,4, Marianne Benn2,3,5, Børge G Nordestgaard1,2,3
1Department of Clinical Biochemistry, Copenhagen University Hospital-Herlev and Gentofte, Copenhagen, Denmark.
Clinical chemistry
|October 31, 2024
概括
低血腺素水平可能与牛皮风险有关,但当考虑肥胖时,这种关联会消失. 遗传学研究没有证实阿迪波涅丁和牛皮之间的因果关系.
科学领域:
- 皮肤病学 皮肤病学
- 内分泌学 在内分泌学.
- 遗传学 是一个遗传学.
背景情况:
- 牛皮是一种慢性炎症性皮肤疾病,经常在肥胖的人群中观察到.
- 来自脂肪组织的抗炎性蛋白质激素阿迪波内克被研究为肥胖和牛皮之间的潜在联系.
- 该研究假设,降低血腺素水平与患上牛皮的风险增加有关.
研究的目的:
- 为了研究血阿迪波涅克水平与牛皮风险之间的关联.
- 探索肥胖是否调解着阿迪波涅克丁和牛皮之间的关系.
- 通过使用遗传数据,评估阿迪波涅丁和牛皮之间的因果关系.
主要方法:
- 观察性分析利用了哥本哈根总人口研究 (CGPS) 中30 045名个体的数据.
- 一个样本的门德尔随机化 (MR) 分析涉及到CGPS的107,308名个人.
- 两种样本的MR分析结合了ADIPOGen的阿迪波内克丁遗传数据与FinnGen (373,338个人) 和英国生物银行 (462,933个人) 的牛皮遗传数据.
主要成果:
- 观察性分析显示,经过年龄/性别调整后,血腺素水平较高的牛皮风险比率降低 (HR 0.67),但在调整肥胖 (HR 0.95) 后,这并不显著.
- 在CGPS中对一个样本的MR分析没有发现基因预测较高的皮素和牛皮风险 (风险比1.33) 之间存在显著的关联.
- 芬兰基因和英国生物银行对两个样本进行的MR分析也显示,基因预测较高的阿迪波涅克丁和牛皮风险 (风险比分别为0.96和1.00) 之间没有显著的关联.
结论:
- 在观察性研究中,仅根据年龄和性别进行调整后,低血腺素与牛皮风险增加有关.
- 在对观察性分析中肥胖度进行调整后,这种关联没有得到支持.
- 因果遗传分析 (门德尔随机化) 不支持阿迪波涅丁和牛皮风险之间的因果关系.
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