转录基因分析确定了cAMP/PKA/CREB信号的丰富在侵袭性叶状乳腺癌中
Susrutha Puthanmadhom Narayanan1, Abdalla M Wedn2,3, Osama Shiraz Shah2
1Division of Oncology, Washington University, St Louis, MO, USA.
Breast cancer research : BCR
|October 31, 2024
概括
侵袭性叶状乳腺癌 (ILC) 显示较高的cAMP/PKA/CREB信号,而不是侵袭性无特殊类型癌症 (NST). 这表明ILC的潜在治疗点,这是一种常见的乳腺癌亚型,缺乏特定的治疗方法.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 基因组学就是基因组学.
背景情况:
- 侵袭性叶状乳腺癌 (ILC) 是一个独特的亚型,具有独特的特征.
- 目前的治疗方法经常将ILC与侵入性癌症 - 没有特殊类型 (NST) 组合在一起,尽管存在差异.
- 需要专门针对ILC的疗法.
研究的目的:
- 识别ILC中的新型分子变化,以开发向治疗.
- 研究cAMP/PKA/CREB信号在ILC中的作用.
主要方法:
- 在三大乳腺癌数据集 (SCAN-B,TCGA,METABRIC) 中进行RNA测序和差异基因表达分析.
- 使用Jaccard相似性的途径分析来识别ILC丰富的途径.
- 使用福斯科林 (cAMP激活剂) 的ILC和NST细胞系和器官的功能研究.
主要成果:
- 在所有数据集中,与NST相比,在ILC中对cAMP/PKA/CREB信号进行一致的调节.
- 在福斯科林治疗后,ILC细胞系和有机体显示-CREB的增加更大.
- ILC细胞系对福斯科林诱导的生长抑制表现出更高的敏感性.
结论:
- 在ILC中,cAMP/PKA/CREB信号传输明显高于NST.
- 这一发现在临床前模型中得到了验证,独立于CDH1状态.
- 对针对ILC这种途径的机制和治疗潜力的进一步研究是有必要的.
相关概念视频
mTOR Signaling and Cancer Progression
3.7K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.7K
PI3K/mTOR/AKT Signaling Pathway
3.4K
The mammalian target of rapamycin (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast, mTORC2 consists of a...
3.4K
Cell Specific Gene Expression
13.5K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
13.5K
Interactions Between Signaling Pathways
6.2K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.2K


