美国成年人中脂质复合指数和喘之间的性别特异关联:来自基于人口的研究的见解
Bufan Ying1, Xiaoxin Liu2, Chengming Yang1
1School of Basic Medical Sciences, Naval Medical University, No 800. Xiangyin Road, Yangpu, Shanghai, 200433, China.
Lipids in health and disease
|October 31, 2024
概括
非高密度胆固醇与高密度胆固醇的比率 (NHHR) 与美国成年人喘患病率相反相关. 这种关系表明喘风险较低,NHHR较高,在男性中更为明显,这表明喘预测的性别特异性影响.
科学领域:
- 心血管健康 心血管健康
- 呼吸系统医学 呼吸系统医学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 脂肪代谢异常经常在成人喘患者中观察到.
- 喘和血脂水平之间的确切关系尚未完全理解.
- 非HDL与HDL比率 (NHHR) 是一种复合脂质指数,可以提供对这种关联的见解.
研究的目的:
- 调查非HDL与HDL比率 (NHHR) 与美国成年人群中喘患病率之间的关联.
- 探索性别对NHHR-喘关系的影响.
主要方法:
- 分析了来自全国健康和营养检查调查 (NHANES) (2009-2018) 的26,023名成年参与者的数据.
- 使用多变量逻辑回归,调整共变量.
- 采用平滑曲线和子组分析来证实研究结果.
主要成果:
- 在日志转换的NHHR和喘患病率 (OR=0.85) 之间发现了显著的反向关联.
- 性别显著调节了这种关联,在男性 (OR=0.78) 与女性 (OR=0.92) 相比,观察到更强的反向关系.
- P-相互作用值为0.0313,表明具有统计学意义的性别影响.
结论:
- 在美国成年人中,NHHR水平和喘患病率之间存在反向关联,受性别的影响.
- 在特定人群中,特别是男性中,NHHR可以作为一种有价值的生物标志物,用于早期识别和预测喘.
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