风湿性关节炎患者的冠状动脉化:系统性审查
Stephanie Nagy1, Jordan Ditchek2, Marc M Kesselman1
1Rheumatology, Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, Davie, USA.
Cureus
|October 31, 2024
概括
患有类风湿性关节炎 (RA) 的患者患心血管疾病的风险更高. 在近60%的RA患者中,通过CT冠状动脉扫描检测到的冠状动脉 (CAC) 评分升高,表明心血管风险增加.
科学领域:
- 类风湿病学 类风湿病学
- 心脏病学 心脏病学
- 放射学 放射学是一门学科.
背景情况:
- 类风湿性关节炎 (RA) 是一种系统性自身免疫性疾病,主要影响关节,但也与心血管疾病 (CVD) 风险增加有关.
- 炎症在RA扩展到突外,对心血管系统产生负面影响,并导致死亡率.
- 不良的心血管结果是RA患者的主要死亡原因.
研究的目的:
- 审查计算机断层扫描 (CT) 冠状动脉扫描在评估RA患者心血管风险方面的实用性.
- 评估RA患者冠状动脉 (CAC) 评分升高的患病率.
- 为了确定RA患者与一般人群相比,是否具有较高的心血管不良结果风险.
主要方法:
- 对305篇文章进行了系统审查.
- 十一篇文章符合审查的纳入和排除标准.
- 使用CT冠状动脉血管学分析冠状动脉 (CAC) 评分,以评估冠状动脉血管化和斑块负担.
主要成果:
- 近60%的类风湿性关节炎患者表现出高的CAC得分.
- 这一发现表明,RA患者冠状动脉样硬化患病率显著更高.
- 与非RA患者相比,RA患者可能面临更大的心血管不良事件风险.
结论:
- 患有RA的患者表现出CAC得分升高的高患病率,这表明心血管风险增加.
- CT冠状动脉扫描是评估RA患者心血管疾病风险的宝贵工具.
- 建议进行进一步的研究,将CT冠状动脉血管学和心血管疾病生物标志物纳入RA管理协议,以减轻心血管并发症.
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