循环拓对线性聚合物对抗菌活性和生物相容性的作用:抗菌形体的抗菌形体
Md Aquib1, Wenting Yang2, Luofeng Yu1,3
1Cluster for Advanced Macromolecular Design (CAMD) and Australian Centre for NanoMedicine (ACN), School of Chemical Engineering UNSW Australia Sydney NSW 2052 Australia.
Chemical science
|October 31, 2024
概括
合成聚合物显示出对抗耐药细菌的前景. 循环聚合物比线性聚合物更具生物相容性,为治疗感染提供了比传统抗生素更安全的替代品.
科学领域:
- 聚合物化学 聚合物化学
- 抗微生物材料 抗微生物材料
- 药物发现 药物发现 药物发现
背景情况:
- 主体防御 (HDP) 是潜在的抗微生物药物,但面临诸如蛋白酶易感性和毒性等挑战.
- 模仿HDPs的合成聚合物为治疗多抗药性 (MDR) 细菌感染提供了替代方案.
- 开发安全有效的合成抗微生物药物需要精心设计聚合物拓和成分.
研究的目的:
- 研究合成两性线性 (LPs) 和循环性聚合物 (CPs) 的抗菌活性和生物相容性.
- 为了将聚合物拓 (LP与CP) 和疏水性含量与抗微生物疗效和哺乳动物细胞毒性相关联.
- 评估这些聚合物作为传统抗生素对抗MDR细菌的替代品的潜力.
主要方法:
- 通过RAFT聚合,合成线性聚合物 (LPs).
- 使用 hetero-Diels-Alder 点击反应将LP循环转化为循环聚合物 (CP).
- 对抗格拉姆阴性细菌的抗菌活性和与哺乳动物细胞的生物相容性的评估.
主要成果:
- 线性聚合物 (LPs) 显示出比循环聚合物 (CPs) 更高的抗菌效果,含乙烯的聚合物表现优于含乙烯基的聚合物.
- 增加的疏水性 (30%比20%) 增加了对细菌和哺乳动物细胞的毒性.
- 聚合物有效地抑制了MDR菌株PA37,超过了仁素和西普洛素,并迅速破坏了细菌膜.
- 与LP相比,循环聚合物 (CPs) 与巨细胞具有更高的血红相容性和生物相容性.
结论:
- 聚合物拓和疏水成分显著影响抗菌活性和生物相容性.
- 循环聚合物为抗微生物应用提供了有前途的疗效与安全平衡.
- 优化聚合物架构和水友性/疏水性比率对于开发有效和选择性的抗微生物聚合物至关重要.
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