较低白细胞预治疗作为可能的风险因素治疗诱导白血病在干扰素β治疗的多发性硬化症患者
Maria Protopapa1, Samantha Schmaul1, Muriel Schraad1
1Department of Neurology, Focus Program Translational Neuroscience, (FTN), and Immunotherapy (FZI), Rhine-Main Neuroscience Network (rmn2), University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
Therapeutic advances in neurological disorders
|October 31, 2024
概括
与标准干扰素β-1a (IFN-β-1a) 相比,化干扰素β-1a (PEG-IFN-β-1a) 在多发性硬化症患者中显著降低了白细胞和中性粒细胞的数量. 这需要监测血液细胞计数,因为副作用增加.
科学领域:
- 免疫学 免疫学 免疫学
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
背景情况:
- 干扰素-β (IFN-β) 对于治疗多发性硬化症 (MS) 和临床隔离综合征 (CIS) 至关重要.
- 基化干扰素β-1a (PEG-IFN-β-1a) 为复发性复发性多发性硬化症 (RRMS) 提供了一种不太频繁的剂量计划.
研究的目的:
- 在RRMS和CIS患者中比较皮下PEG-IFN-β-1a和皮下IFN-β-1a之间的实验室发现和不良事件.
- 评估这些治疗对疾病进展和实验室参数的影响.
主要方法:
- 在2010-2019年期间治疗的128名CIS或RRMS患者的回顾性分析.
- 通过电话采访评估临床和MRI疾病活动,实验室发现 (白血病,中性质衰竭) 和不良事件.
- 对中性粒细胞数量和质量的亚组分析.
主要成果:
- 与皮下IFN-β-1a治疗相比,皮下PEG-IFN-β-1a治疗导致白细胞数量显著降低,白血病和中性病的发病率更高.
- 两组之间没有观察到临床或MRI评估疾病活性的显著差异.
- 接受皮下PEG-IFN-β-1a治疗的患者报告了更多不良事件,包括疼痛和感染,但没有发生严重不良事件.
结论:
- 皮下PEG-IFN-β-1a显著降低白细胞和中性粒细胞水平,比未化皮下IFN-β.
- 随着皮下注射PEG-IFN-β-1a.a,人们注意到副作用的增加.
- 建议在使用这些药物治疗前和治疗期间强制监测不同血细胞计数.
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