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Microorganisms in Medicine and Therapeutics

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.

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Updated: Jun 9, 2025

Intrasplenic Transplantation of Hepatocytes After Partial Hepatectomy in NOD.SCID Mice

Intrasplenic Transplantation of Hepatocytes After Partial Hepatectomy in NOD.SCID Mice

Published on: February 10, 2018

针对急性肝衰竭的微生物疗法目前的进展.

Jiayuan Huang¹, Tianyu Xu¹, Guoqiao Quan¹

¹Department of Gastroenterology, Research Center for Engineering Techniques of Microbiota-Targeted Therapies of Guangdong Province, The First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou, China.

Frontiers in microbiology

|October 31, 2024

概括

基于微生物群的治疗方法对急性肝衰竭 (ALF) 有希望,这是一个严重的疾病,死亡率高. 本综述探讨了如何针对肠道微生物群可以帮助ALF预防,治疗和改善患者的治疗结果.

关键词:

急性肝衰竭是一种严重的肝衰竭.急性肝损伤是什么?便微生物群移植肠 - 肝 - 轴的时间.我们的微生物群.益生菌是一种益生菌.甲型肝脏脑病变是一种肝脏脑病变.

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Last Updated: Jun 9, 2025

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科学领域:

肝病学肝病学是一种肝病学.
微生物学微生物学
胃肠病学胃肠病学

背景情况:

急性肝衰竭 (ALF) 是一种严重的临床疾病,死亡率超过80%.
人们越来越认识到肠道微生物群在ALF病原和进展中的作用.
对于ALF的微生物群为基础的干预措施存在有限的综合性审查.

研究的目的:

批判性地检查基于微生物群的ALF治疗方法.
审查这些治疗方法的机制和疗效.
评估它们在过去十年对ALF预防,治疗和预后的影响.

主要方法:

文献综述侧重于针对ALF的基于微生物群的干预措施.
对过去十年内发表的研究进行分析.
检查机制,疗效,预防,治疗和预后.

主要成果:

越来越多的证据支持宿主微生物群相互作用对ALF的影响.
基于微生物群的策略正在成为潜在的治疗途径.
需要进一步的研究,以充分阐明治疗的有效性和机制.

结论:

微生物群调节为管理ALF提供了一个有希望的前沿.
了解这些相互作用对于开发新的治疗策略至关重要.
本次审查强调了对基于微生物群的ALF治疗方法的持续调查的必要性.