齐可诺提德和精神病:从病例报告到范围审查
Marc Peraire1,2, Rita Gimeno-Vergara1,2, Jennifer Pick-Martin1,2
1TXP Research Group, Universidad Cardenal Herrera-CEU, CEU Universities, Castellón de la Plana, Spain.
Frontiers in molecular neuroscience
|October 31, 2024
概括
齐科诺提德是一种N型止痛通道阻塞剂,可引起诸如精神病等多种神经精神病学影响. 这些症状可能源于它对神经递质通路的影响.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 临床医学 临床医学
背景情况:
- 齐科诺提德是一种非阿片类止痛药,向N型电压通道.
- 虽然对疼痛有效,但齐科诺提德与神经精神病学不良影响有关.
研究的目的:
- 为了呈现一种由齐可诺提德诱导的精神病症.
- 探索齐科诺提德的神经精神病症状的范围及其机制.
主要方法:
- 一个临床案例的西科诺提德诱导的精神病被记录在案.
- 使用Web of Science,PubMed和Embase进行了对已发表文献的范围审查.
- 在文献搜索中遵循了PRISMA-ScR指南.
主要成果:
- 本案例说明了单个患者多种神经精神症状.
- 范围审查确定了13篇相关论文,详细介绍了21例与齐可诺提德有关的神经精神病学影响,包括精神病和妄想.
- 副作用的范围从轻微到严重的神经精神障碍.
结论:
- 齐科诺的神经精神症状可能源于N型通道阻塞在质和GABAergic神经元中.
- 这种阻塞可能会破坏多巴胺基通路,导致观察到的精神效应.
- 了解这些机制对于管理可诺提德治疗至关重要.
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