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相关概念视频

Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...
Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin D3(cholecalciferol).
Cells of the Epidermis01:24

Cells of the Epidermis

The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
Reticular Dermis01:15

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...

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重组纤维蛋白凝作为皮肤膏中的风湿学修饰剂

Dustin Britton1, Jonathan Sun1,2, Hammad Ali Faizi3

  • 1Department of Chemical and Biomolecular Engineering, New York University Tandon School of Engineering, Brooklyn, New York 11201, United States.

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概括
此摘要是机器生成的。

一种新型的蛋白质水凝,Q5,在低pH下增强皮肤奶油材料的强度. 与传统选择相比,这种响应pH的风湿修饰剂在个人护肤产品中提供了更好的性能.

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科学领域:

  • 材料科学 材料科学 材料科学
  • 生物技术是生物技术.
  • 化品科学 化品科学

背景情况:

  • 风湿修饰剂对于个人护肤产品 (PSCPs) 中的皮肤 (SC) 底盘至关重要.
  • SC粘度会影响PSCP的有效性,加工,储存和活性成分的输送.
  • PSCPs需要SCs,在皮肤的轻微酸性环境中保持材料强度.

研究的目的:

  • 为了研究PSCP中对pH响应性风湿学修饰的卷轴-卷轴蛋白质水凝系统.
  • 为了评估一个设计的蛋白质变体,Q5,对其形成水凝和增强材料强度在酸性pH的能力.
  • 为了比较Q5作为一种与基乙烯纤维素 (HEC) 相比的风湿修饰剂的性能,在标准的SC.

主要方法:

  • 设计了一种螺旋-螺旋蛋白质水凝变体 (Q5),具有低同电点 (pI).
  • 评估了Q5在不同pH值 (6.0和8.0) 的溶液-凝过渡和质性质.
  • 将Q5纳入标准的SC配方中,并与HEC相比评估其材料强度.

主要成果:

  • Q5在pH值为6.0时显示了部分溶液到凝的过渡,作为软水凝起作用.
  • 与HEC相比,Q5在低pH (6.0) 时独特地增加了SC的材料强度.
  • 基于蛋白质的水凝显示了与皮肤状况相关的pH依赖性风湿性行为.

结论:

  • 基于蛋白质的模块化卷轴-卷轴的风湿学修饰剂,如Q5,适合PSCPs.
  • Q5在酸性pH下提供了增强的材料强度,解决了SC配方中的一个关键挑战.
  • 这种蛋白质水凝系统为个人护理产品的传统风湿修饰剂提供了一个有希望的替代品.