验证从指尖光电显微镜中对中央大动脉压力波形的非侵入性导出,使用一种新的选择性转移函数方法
James R Cox1, Ehad Akeila2, Alberto P Avolio1,2
1Macquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia.
Pulse (Basel, Switzerland)
|October 31, 2024
概括
摄影脉冲图 (PPG) 提供了一种非侵入性方法来评估中枢大动脉压力波形. 使用选择性转移函数 (TF) 进行指尖PPG测量,与放射性度的结果非常相匹配,表明其临床潜力.
科学领域:
- 心血管生理学心血管生理学
- 生物医学工程 生物医学工程
- 非侵入性的血液动力学监测
背景情况:
- 中央大动脉压力波形分析提供了宝贵的临床数据,超出了手臂血压 (BP).
- 中央大动脉波形的非侵入性复制通常使用具有通用转移函数 (GTF) 的平面化度学.
- 摄影电磁镜 (PPG) 提供了一个替代方案,但由于测量差异,需要特定的传递函数 (TF).
研究的目的:
- 为了比较从放射性度学 (参考) 获得的中央大动脉波形特征与指尖PPG的特征.
- 评估基于信号波形状的PPG衍生的中央大动脉波形的新型选择性TF方法.
主要方法:
- 在21名参与者中,同时进行了放射性度和指尖PPG测量.
- 中央大动脉波形是使用专有GTF用于度和选择性TF用于PPG生成的.
- 通过使用统计分析和RMSE,比较了20个中央大动脉压力波形参数和波形形状.
主要成果:
- 在PPG衍生的参数和度学衍生的参数之间观察到高相关性 (r=0.79-0.99).
- 压力和时间参数的平均差异在生理上是微不足道的.
- 中央大动脉波形形状比较显示,根-平均-平方误差 (RMSE) 低,为1.8 ± 0.9%.
结论:
- 使用选择性TF的指尖PPG可以产生与放射性度相比的中央大动脉波形参数.
- 这种非侵入性PPG方法表明了准确中央大动脉压力波形评估的潜力.
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