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在 Salivary Gland Carcinoma-A 多中心研究中使用18 F-FDG PET/CT进行放射后治疗反应评估

Po-Yuan Chen¹, Nai-Ming Cheng, Chien-Yu Lin¹

¹From the Radiation Oncology.

Clinical nuclear medicine

|October 31, 2024

概括

18F-FDG PET/CT有效评估了唾液腺癌 (SGC) 的治疗后反应. 对PET/CT的代谢完整反应表明了出色的结果,并有助于早期检测可活性的瘤.

科学领域:

核医学成像技术核医学成像技术
在瘤学瘤学.
辐射疗法反应评估评估辐射疗法反应评估

背景情况:

唾液腺癌 (SGC) 在治疗后的评估中提出了挑战.
准确评估治疗反应对于患者的管理和预后至关重要.

研究的目的:

调查18F-FDG PET/CT在评估SGC中放射治疗后 (RT后) 反应中的有效性.
为了确定对患者结果的代谢反应的预测值.

主要方法:

对115名接受放射治疗,随后接受18F-FDG PET/CT.的SGC患者进行了回顾性审查.
分析局部区域对照,远程无转移生存率,无进展生存率和整体生存率.
评估PET/CT性能指标,包括灵敏度,特异性和预测值.

主要成果:

18F-FDG PET/CT在70%的患者中发现了完全代谢反应 (CR).
代谢性CR与显著改善的5年局部区域控制 (90%与43%相比),远程无转移生存 (80%与48%),无进展生存 (76%与24%) 和整体生存 (89%与42%相比) 相关.
在预测复发方面,PET/CT表现出高特异性 (91%) 和负预测值 (88%),并且对高RT前SUVmax的瘤具有更高的敏感性.

结论:

后RT 18F-FDG PET/CT是SGC响应评估的一个有价值的工具,证明了高特异性和负预测价值.
对PET/CT的代谢CR预测出色的长期结果.
18F-FDG PET/CT促进了可活性的瘤的早期检测,特别是在高SUVmax的SGC中,有助于及时的救援治疗决策.

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