纳米酶作为葡萄糖清除剂和氧气生成器,用于增强瘤放射治疗
Yuxuan Zhang1, Xingchen Li2, Xiaojun Ren1
1Department of Radiation Oncology, The Second Affiliated Hospital of Jilin University, Changchun 130041, P. R. China.
ACS applied materials & interfaces
|October 31, 2024
概括
金纳米酶通过增强活性氧物种 (ROS) 和增强放射治疗来克服瘤缺氧和辐射抵抗. 这些纳米酶改善瘤成像和饥饿癌细胞,增加治疗效率.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 辐射疗法 辐射疗法
背景情况:
- 瘤缺氧增加了辐射抵抗力,阻碍了放射治疗 (RT) 的疗效.
- 增强活性氧物种 (ROS) 和减轻缺氧是提高辐射敏感性的关键策略.
研究的目的:
- 开发自级催化-金 (Pt@Au) 纳米酶作为放射敏感剂,以对抗瘤缺氧并增强RT.
- 研究Pt@Au纳米酶在改善瘤微环境和治疗结果方面的多功能活动.
主要方法:
- 合成的Pt@Au纳米酶具有类似于葡萄糖氧化酶 (GOx),催化酶 (CAT) 和过氧化酶 (POD) 的活性.
- 纳米酶被评估其消耗葡萄糖,产生和转化过氧化 (H2O2) 和产生氧气 (O2) 的能力.
- 用X射线计算机断层扫描 (CT) 图像用于瘤可视化和精确的RT准.
主要成果:
- Pt@Au纳米酶表现出GOx类活性,耗尽葡萄糖并产生H2O2,启动饥饿疗法和级联反应.
- 类似于CAT的活性将H2O2转化为O2,缓解瘤缺氧并稳定ROS.
- 类似POD的活动产生基基 (·OH),进一步增加ROS和DNA损伤,而Pt@Au纳米酶增强了X射线能量沉积和CT成像.
结论:
- 自式Pt@Au纳米酶通过解决瘤缺氧和增加ROS水平,有效地增强辐射敏感性.
- 这些纳米酶提供了饥饿疗法和增强的RT的双重治疗方法,加上改善的瘤成像能力.
- Pt@Au纳米酶代表了一种有前途的策略,用于克服缺氧瘤中的电阻,并推进癌症治疗.
更多相关视频
06:51Utilizing 18F-FDG PET/CT Imaging and Quantitative Histology to Measure Dynamic Changes in the Glucose Metabolism in Mouse Models of Lung Cancer
Published on: July 21, 2018
17.9K
07:54Surface-enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detecting Microscopic Ovarian Cancer via Folate Receptor Targeting
Published on: March 25, 2019
8.1K
相关概念视频
02:49Cancer Therapies
7.6K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.6K
02:53Adaptive Mechanisms in Cancer Cells
5.7K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.7K
01:46Electron Transport Chain: Complex I and II
11.9K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
ROS generation is regulated and maintained at moderate levels necessary...
11.9K