连续输注piperacillin/tazobactam优化了在接受选择性骨盆外出手术的患者手术期间的抗生素暴露
Dwane Jackson1,2,3, Marta Ulldemolins4,5, Xin Liu4
1Department of Anaesthesia and Perioperative Medicine, Royal Brisbane and Women's Hospital, Brisbane, Australia.
Antimicrobial agents and chemotherapy
|October 31, 2024
概括
在盆腔外腔手术中优化皮佩拉西林/塔扎巴克坦剂量至关重要. 持续输注较低剂量可确保足够的抗生素暴露,特别是在高风险患者.
科学领域:
- 药理学 药理学是指药理学的学科.
- 手术瘤学手术瘤学
- 传染性疾病 传染性疾病
背景情况:
- 接受盆腔排泄的患者有低于最佳的抗生素水平的风险.
- 在这种情况下,piperacillin/tazobactam通常用于手术预防.
研究的目的:
- 为了研究皮佩拉西林/塔扎巴克坦在接受盆腔排泄的患者中的药理动力学.
- 为在手术期间接触抗生素时制定最佳的剂量建议.
主要方法:
- 展望性,观察性药理动力学研究.
- 使用Monolix和Simulx进行的人口药动力学分析和蒙特卡洛模拟.
- 对MIC断点的目标实现概率的计算.
主要成果:
- 一个两部分线性模型描述了piperacillin和tazobactam的药理动力学.
- 在大多数患者中,连续输注2g/0.25g负载剂量,其次是4g/0.5g q8h,实现了MIC=16 mg/L的目标.
- 患者≥100公斤或GFR≥120毫升/分钟需要4g/0.5g q6h连续输注.
结论:
- 连续输注piperacillin/tazobactam是有效的手术预防在盆腔排泄.
- 当前的指导方针可能需要对体重或GFR较高的患者进行调整.
- 优化剂量可确保足够的手术内抗生素暴露.
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