饮食变化和结肠直肠癌风险在英国生物银行
Tung Hoang1,2,3, Sooyoung Cho1,4, Aesun Shin1,2,4,5
1Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.
概括
增加水果和蔬菜的摄入量显著降低了男性结直肠癌的风险. 饮食变化可能会影响癌症风险,强调健康饮食习惯对预防的重要性.
科学领域:
- 营养流行病学 营养流行病学
- 预防癌症 预防癌症
- 公共卫生 公共卫生
背景情况:
- 饮食行为显著影响结肠直肠癌 (CRC) 风险.
- 向更健康的饮食模式改变习惯可能会减轻CRC的风险.
- 了解饮食变化对CRC发病率的影响对于公共卫生战略至关重要.
研究的目的:
- 调查饮食习惯的变化与患结直肠癌的风险之间的关联.
- 分析遵守肉类,水果,蔬菜和酒精消费的饮食建议如何影响CRC风险.
- 确定可以减轻CRC风险的特定饮食修改.
主要方法:
- 根据饮食建议将50,640名英国生物库参与者分为不良和良好的坚持群体.
- 定义饮食变化为稳定贫困,穷到好,好到穷,稳定到良好的坚持.
- 采用了Cox的比例危险模型来评估饮食变化与CRC风险之间的关系.
主要成果:
- 增加水果和蔬菜消费 (每天≥5份) 与男性CRC风险降低有关 (HR:0.24).
- 这种有益的关联在女性中没有统计学意义 (HR:0.41).
- 在平均3.3年的随访期间,16.4%的人改善了饮食,而11.5%的人饮食恶化.
结论:
- 增加水果和蔬菜摄入量是减轻结直肠癌风险的有益策略,特别是在男性中.
- 在英国生物银行队列中观察到饮食坚持变化.
- 研究结果支持特定饮食改善在预防癌症中的作用.
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