相关实验视频
Updated: Jun 9, 2025

08:22
A Preclinical Model of Exertional Heat Stroke in Mice
Published on: July 1, 2021
3.7K
一个基于系统免疫系统发炎指数的动态演变价值的命名程序,用于评估严重的热中风
Chongxiao Xu1, Bingling Yin2, Yueli Zhao3
1Weifang People's Hospital, Shandong, China.
Shock (Augusta, Ga.)
|October 31, 2024
概括
严重热中风的第三天的全身免疫炎症指数 (SII) 是死亡率的关键预测指标. 将SII与SOFA得分相结合,可以改善热中风患者的预后.
科学领域:
- 临床医学 临床医学
- 炎症研究 炎症研究
- 预测生物标志物 预测生物标志物
背景情况:
- 严重的热中风具有很高的死亡风险.
- 对热中风炎症反应的临床理解是有限的.
- 系统性免疫炎症指数 (SII) 是一种新的系统性炎症标志物.
研究的目的:
- 调查系统性免疫炎症指数 (SII) 对严重热中风患者死亡率的预测值.
- 确定SII,特别是第三天 (SII 72),是否可以预测预后.
- 评估SII 72和SOFA评分的联合预测能力.
主要方法:
- 对177名严重热中风患者 (2010-2023) 的回顾性观察研究.
- 多变量逻辑回归和名图分析,以评估SII的预测能力.
- 基于SII水平的子组分析和不同天的SII比较.
主要成果:
- 死亡率为15.8% (28/177名患者).
- 第1天和第2天的SII值没有显著预测死亡率.
- 升高的SII 72与增加的死亡率显著相关 (P=0.035).
- 无论是SOFA得分还是SII 72都独立预测死亡率.
- 与单独使用SOFA相比,SII 72和SOFA评分的组合显示出更高的预测性能.
结论:
- 第三天SII (SII 72) 是一个比早期测量更有意义的预测者,比较糟糕的热中风预后.
- SII 72 作为严重热中风的有价值的预后指标.
- 将SII 72与SOFA得分相结合,可以提高热中风患者死亡率的预测.
相关概念视频
Methods of reducing fever
643
The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:
Pharmacological Methods of Reducing Fever:
643
Inflammatory Response I: Vascular and Cellular
10.9K
The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
10.9K
Homeostatic Imbalances in Body Temperature
106
Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
106
Increased Body Temperature
645
A body temperature above 38°C (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
645
Myocarditis IV: Nursing Management
2
Myocarditis is an inflammatory condition of the myocardium requiring meticulous nursing management for optimal patient outcomes. Effective management begins with a thorough assessment of the patient's medical history, paying close attention to past infections, autoimmune disorders, travel history, and exposure to toxins or drugs. Recent viral infections and systemic diseases are particularly relevant due to their potential role in triggering myocarditis.Physical Examination and MonitoringThe...
2
Requirements for Human Life
7.8K
The Earth and its atmosphere have provided humans with air, water, and food, but these are not the only requirements for survival. Humans also require a specific range of temperature and pressure that the Earth and its atmosphere provides.
Oxygen
Atmospheric air is only about 20 percent oxygen, but that oxygen is a key component of the chemical reactions that keep the body alive, including the reactions that produce ATP. Brain cells are susceptible to a lack of oxygen because they require a...
Oxygen
Atmospheric air is only about 20 percent oxygen, but that oxygen is a key component of the chemical reactions that keep the body alive, including the reactions that produce ATP. Brain cells are susceptible to a lack of oxygen because they require a...
7.8K

