两种碳酸酶抑制剂对急性缺氧运动表现的影响
Jou-Chung Chang1, Benjamin P Thompson1, Connor J Doherty1
1Department of Kinesiology and Health Sciences, Faculty of Health, University of Waterloo, Waterloo, Ontario, Canada.
Journal of applied physiology (Bethesda, Md. : 1985)
|October 31, 2024
概括
乙胺 (AZ) 和甲胺 (MZ) 都会减缓急性缺氧的全身运动性能. 两种药物都没有改善通风或氧和,尽管引起了代谢性酸.
科学领域:
- 运动医学 运动医学
- 高度生理学 高度生理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 急性山病 (AMS) 是快速登期间的一个担忧.
- 乙胺 (AZ) 是一种常见的AMS预防药物,但可能会影响运动.
- 甲胺 (MZ) 类似于AZ,但可能不会影响单独的肌肉性能.
研究的目的:
- 为了比较AZ,MZ和安慰剂 (PLA) 对急性缺氧中全身运动表现的影响.
- 为了研究在这些条件下炼期间的生理反应.
主要方法:
- 15名健康参与者完成了一项随机,双盲,安慰剂控制的研究.
- 参与者接受了AZ,MZ或PLA的2天剂量后的5公里低氧自行车时间试验.
- 测量包括运动表现,血液气体,通风和氧和.
主要成果:
- 与PLA相比,AZ和MZ都显著减缓了5公里计时试验的性能.
- 在AZ和MZ之间没有观察到运动表现的显著差异.
- 这两种药物都在休息状态下诱导了部分补偿的代谢酸,而不会影响通风或氧和.
结论:
- 乙胺和甲胺都会在急性诺莫巴里克缺氧中降低全身运动性能.
- 在AZ和MZ之间,导致绩效受损的机制可能有所不同.
- 需要进一步的研究来探索这些药物的独特生理影响.
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