维生素D缺乏和儿科阻塞性睡眠呼吸暂停的严重程度
Andrew E Bluher1,2, Timothy Kearney3, Turaj Vazifedan4
1Division of Pediatric Otolaryngology, Nemours Children's Hospital, Wilmington, Delaware.
JAMA otolaryngology-- head & neck surgery
|October 31, 2024
概括
维生素D缺乏症在患有严重阻塞性睡眠呼吸暂停 (OSA) 的儿童中很常见,并且与OSA严重程度的恶化有关. 需要对儿科OSA的维生素D补充进行进一步的研究.
科学领域:
- 儿科耳鼻喉科 儿科耳鼻喉科
- 睡眠医学 睡眠医学
- 营养科学 营养科学
背景情况:
- 新出现的证据表明,在成年人中,维生素D缺乏和阻塞性睡眠呼吸暂停 (OSA) 之间存在联系.
- 维生素D水平和儿科OSA之间的关联不太清楚.
- 维生素D缺乏是影响儿童OSA严重性的潜在因素.
研究的目的:
- 调查血清维生素D水平与儿童阻塞性睡眠呼吸暂停 (OSA) 严重程度之间的关联.
- 评估维生素D缺乏与儿童OSA患者的呼吸暂停-呼吸暂停指数 (AHI) 之间的相关性.
主要方法:
- 对72名患有严重OSA (AHI ≥20) 的儿童 (年龄在2-16岁) 进行横截面研究,这些儿童接受了腺切除术.
- 测量了血清25-氧维生素D (25[OH]D) 水平;缺乏被定义为<20 ng/mL.
- 统计分析,包括单变量和多变量模型,评估了维生素D水平和AHI之间的关联,控制年龄,性别,种族,BMI,喘和季节.
主要成果:
- 在37.5%的参与者中,存在维生素D缺乏.
- 在单变量分析中,维生素D缺乏与年龄较小,黑人种族,女性性别和更高的AHI有关.
- 多变量分析证实了较低的维生素D水平和增加的AHI之间存在显著的关联 (每1.0单位减少25[OH]D的AHI增加0.7个单位).
结论:
- 维生素D缺乏症在患有严重OSA的儿童中很常见,并且与OSA严重程度的增加显著相关.
- 这些发现强调了评估儿科OSA维生素D状况的重要性.
- 进一步研究维生素D补充作为儿科OSA的辅助疗法是有必要的.
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