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一个Alcaligenes nematophilus菌株EBU-23编码bla基因的第一基因组序列数据与儿童急性胃肠炎有关

Ebuka Elijah David^1,2, Ikechuku Okorie Igwenyi³, Ifeanyichukwu Romanus Iroha⁴

¹Department of Biochemistry, Alex Ekwueme Federal University, Ndufu-Alike, Ikwo, Nigeria. david.ebuka@funai.edu.ng.

Current microbiology

|October 31, 2024

概括

这项研究测序了尼日利亚一名婴儿胃肠炎病例的扩展谱β-乳糖酶 (ESBL) 生产Alcaligenes nematophilus菌株的基因组. 这些发现凸显了临床环境中多药耐药细菌的出现.

科学领域:

微生物学微生物学
基因组学就是基因组学.
传染性疾病传染性疾病

背景情况:

曾经被认为是环境污染物的类物种,在临床感染中越来越多地被发现.
细菌病原体中出现抗生素耐药性的出现构成了全球健康的重大威胁.

研究的目的:

为了执行扩展光谱β-乳糖酶 (ESBL) 生产Alcaligenes nematophilus菌株的全基因组测序.
在这个临床隔离体中调查多药耐药性的遗传基础.

主要方法:

对Alcaligenes nematophilus菌株EBU-23.3.的全基因组测序进行了研究.
抗生素敏感性测试. 抗生素敏感性测试.
基因组分析以识别耐药基因.

主要成果:

这项研究确定了一种ESBL产生的Alcaligenes nematophilus菌株 (EBU-23) 来自尼日利亚的一名患有急性胃肠炎的婴儿.
该分离物对多种抗生素类别呈现耐药性,包括β-乳酸盐,,青素和诺基诺.
基因组分析揭示了一种A类β-乳酸酶基因和多种多重药物排泄透.

结论:

这是尼日利亚首个与急性儿童胃肠炎相关的多药耐药Alcaligenes nematophilus菌株的全基因组序列.
鉴定出的抗药性基因可能有助于观察到的多药性抗药性表型.
这些发现强调了Alcaligenes物种日益增长的临床意义以及对抗性菌株的监测的必要性.

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