在资源有限的环境中,FOLFOXIRI用于第一线治疗无法切除的结肠直肠癌与肝转移
Vuong Dinh Thy Hao1, Phan Minh Tri2,3, Doan Tien My3
1Chemotherapy Department, Cancer Center, Cho Ray Hospital, Ho Chi Minh City, Vietnam.
Journal of gastrointestinal cancer
|October 31, 2024
概括
在越南,FOLFOXIRI化疗在结直肠癌肝转移方面显示出有希望的结果. 这种治疗改善了反应率和生存率,在低至中等收入国家环境中证明了其有效性.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 临床试验 临床试验
背景情况:
- 在低收入至中等收入国家 (LMICs) 的不可切除结直肠癌 (CRC) 肝转移的FOLFOXIRI化疗数据有限.
- 本研究评估了FOLFOXIRI在越南LMIC环境中的使用情况.
研究的目的:
- 在越南评估FOLFOXIRI在患有无法切除的结直肠癌肝转移的患者中的安全性和有效性.
- 解决关于FOLFOXIRI在LMIC环境中的使用知识差距.
主要方法:
- 一项前性研究招募了92名患有无法切除的CRC肝转移的患者.
- 患者每隔2周接受FOLFOXIRI,并进行G-CSF预防.
- 结果包括R0/R1切除率,无进展生存率 (PFS),总生存率 (OS),客观反应率 (ORR),疾病控制率 (DCR) 和不良事件 (AE).
主要成果:
- 客观应答率 (ORR) 为85.1%,疾病控制率 (DCR) 为95.4%.
- 62%的患者实现了切除能力,R0/R1切除率为88.9%.
- 中位数的PFS为13个月,中位数的OS为22个月;34.8%的人经历了严重的不良事件.
结论:
- 福尔福西里显著改善了结直肠癌肝转移的响应率,切除率和存活率.
- 需要进一步的研究来优化FOLFOXIRI的疗效,并尽量减少LMIC人口中的毒性.
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