患有多发性硬化症的人群中的癌症和死亡风险:伊朗伊斯法罕的一项基于人口的研究
Amirhossein Nafari1, Saeed Vaheb1, Alireza Afshari-Safavi1,2
1Isfahan Neurosciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
PloS one
|October 31, 2024
概括
多发性硬化症 (MS) 患者的癌症风险显著,特别是在老年人中. 男性性别和较长的MS持续时间与癌症死亡风险增加有关.
科学领域:
- 神经学 神经学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 多发性硬化症 (MS) 和癌症是全球主要的健康问题.
- 由于潜在的人口和地理差异,了解MS患者 (PwMS) 的癌症模式至关重要.
- 伊朗伊斯法罕省的MS发病率很高,为研究MS与癌症关联提供了关键人口.
研究的目的:
- 调查癌症风险与多发性硬化症 (MS) 之间的关联.
- 分析MS (PwMS) 患者癌症发病率和死亡率的模式.
主要方法:
- 利用了来自伊朗国家多发性硬化病登记系统 (NMSRI) 的数据用于PwMS.
- 使用伊朗国家基于人口的癌症登记 (INPCR) 数据分析了癌症发病率.
- 采用描述性统计,回归分析和卡普兰-梅尔生存分析.
主要成果:
- 在10,049名PwMS中,123人被诊断出患有癌症.
- 癌症发病率为每10万人/年125.6,在60-64岁年龄组达到顶峰.
- 单克隆抗体使用和年龄较大与更高的癌症风险相关;男性性别和更长的MS持续时间与癌症死亡率增加有关.
结论:
- 在患有多发性硬化症的人群中,癌症发病率显著.
- 乳腺癌是最常见的恶性瘤,特别是在女性中.
- 男性性别和更长的疾病持续时间是PwMS癌症死亡率的风险因素.
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