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周 papillary 血管的密度与大脑白质的超强度密切相关:一个 OCTA 研究
Yuanyue Song1, Zehua Lai1, Kaiqi Ding1
1Department of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
PloS one
|October 31, 2024
概括
光学连贯断层血管造影 (OCTA) 显示,在患有白质超强度 (WMHs) 的患者中,视网膜外皮血管密度降低. 这一发现表明,OCTA可以帮助评估大脑小血管疾病的严重程度.
科学领域:
- 神经科学是一个神经科学.
- 眼科医生 眼科 眼科
- 放射学 放射学是一门学科.
背景情况:
- 慢性大脑低流导致白质过强度 (WMHs),这是大脑小血管疾病 (CSVD) 的标志.
- 目前的成像无法可视化小脑血管,视网膜与WMHs的联系尚不清楚.
- 光学连贯断层血管造影 (OCTA) 提供了视网膜血管评估的潜力.
研究的目的:
- 用OCTA在WMHs患者中研究视网膜血管变化.
- 探索视网膜微循环和WMH严重程度之间的相关性.
- 评估OCTA作为一种评估早期缺血性大脑WMHs perfusion 的方法.
主要方法:
- 49名WMH患者根据MRI评估的严重程度 (轻度与中度/重度) 进行分组,使用Fazekas和Scheltens尺度.
- OCTA用于测量底部血管的微循环.
- 逻辑回归和ROC曲线分析了相关性和诊断疗效.
主要成果:
- 中度/严重的WMH组在上方象限 (p <0.05) 中显示出明显较低的周周血管密度 (VD).
- 结合年龄,糖尿病和上象限VD,通过ROC分析检测WMH严重性的特异性为94.1%.
结论:
- 周 papillary 血管密度与大脑WMH严重程度密切相关.
- 早期的低 perfusion 变化可能起源于光盘的内层.
- OCTA提出了一种新的方法,用于评估缺血性WMHs的血液 perfusion.
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