Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Mismatch Repair01:36

Mismatch Repair

39.9K
Overview
39.9K
Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

1.4K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.4K
Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

2.5K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
2.5K
Infection01:20

Infection

7.7K
When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
7.7K
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic01:26

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

4.0K
Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
4.0K
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

A randomized, double-blind, controlled, parallel group study with amustaline/glutathione pathogen reduced red blood cells in regions at potential risk for Zika virus transfusion-transmitted infections (RedeS Study)-protocol for a phase 3 clinical trial.

Trials·2026
Same author

A microbiologist's field guide to community ecology.

ISME communications·2026
Same author

The impact on image formation of inevitable tip bending with modern high resolution atomic force microscopy probes.

Nanoscale·2026
Same author

Mycobacterium smegmatis Expands Across Surfaces by Hydraulic Sliding.

Environmental microbiology reports·2025
Same author

Cell wall mechanical stress could coordinate septal synthesis and scission in <i>Staphylococcus aureus</i>.

mBio·2025
Same author

Assessing the Mechanism of Action of Synthetic Nanoengineered Antimicrobial Polymers against the Bacterial Membrane of <i>Pseudomonas aeruginosa</i>.

Biomacromolecules·2025

相关实验视频

Updated: Jun 9, 2025

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA

Published on: February 9, 2011

22.9K

两种相互依赖的途径导致高水平的MRSA

Abimbola Feyisara Adedeji-Olulana1, Katarzyna Wacnik2,3, Lucia Lafage2,3

  • 1School of Mathematical and Physical Sciences, University of Sheffield, Sheffield, UK.

Science (New York, N.Y.)
|October 31, 2024
PubMed
概括

甲素耐药黄杆菌 (MRSA) 改变细胞分裂和糖结构以抵抗抗生素. 针对这些抵抗机制的新药提供了治疗机会.

更多相关视频

Multiplex PCR Assay for Typing of Staphylococcal Cassette Chromosome Mec Types I to V in Methicillin-resistant Staphylococcus aureus
09:03

Multiplex PCR Assay for Typing of Staphylococcal Cassette Chromosome Mec Types I to V in Methicillin-resistant Staphylococcus aureus

Published on: September 5, 2013

11.9K
Methodology for the Study of Horizontal Gene Transfer in Staphylococcus aureus
10:39

Methodology for the Study of Horizontal Gene Transfer in Staphylococcus aureus

Published on: March 10, 2017

16.6K

相关实验视频

Last Updated: Jun 9, 2025

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA

Published on: February 9, 2011

22.9K
Multiplex PCR Assay for Typing of Staphylococcal Cassette Chromosome Mec Types I to V in Methicillin-resistant Staphylococcus aureus
09:03

Multiplex PCR Assay for Typing of Staphylococcal Cassette Chromosome Mec Types I to V in Methicillin-resistant Staphylococcus aureus

Published on: September 5, 2013

11.9K
Methodology for the Study of Horizontal Gene Transfer in Staphylococcus aureus
10:39

Methodology for the Study of Horizontal Gene Transfer in Staphylococcus aureus

Published on: March 10, 2017

16.6K

科学领域:

  • 微生物学
  • 分子生物学
  • 生物化学

背景情况:

  • 由于其对β-乳糖抗生素的耐药性,甲素耐药黄金葡萄球菌 (MRSA) 是一个重要的临床威胁.
  • 这种抗药性主要由编码青素结合蛋白2a (PBP2a) 的mecA基因赋予.

研究的目的:

  • 研究MRSA在抗生素的存在下维持生命力和分裂的细胞和分子机制.
  • 通过了解MRSA抗生素耐药性的策略来确定潜在的新疗法目标.

主要方法:

  • 在抗生素压力下对MRSA细胞分裂和糖合成进行比较分析.
  • 对必要的青素结合蛋白 (PBPs) 的基因分析和补偿突变的鉴定.

主要成果:

  • 当暴露于抗生素时,MRSA表现出细胞分裂模式和分裂隔膜上的糖结构变化.
  • PBP2a可以替代PBP2的转酶活性,但不能替代PBP1的转酶活性,这对于原生隔膜糖来说至关重要.
  • 在没有PBP1活性的情况下,染色体增强剂 (pot) 突变使MRSA分裂.

结论:

  • MRSA利用了涉及PBP2a活性和高水平抗生素耐药性的替代分裂途径的双重机制.
  • 针对这些相互关联的耐药性机制是开发新型MRSA复敏剂的有希望的策略.