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Updated: Jun 9, 2025

Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions
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Author Spotlight: A Computational Approach to Decipher Amino Acid Preferences in Multispecific Protein-Protein Interactions

Published on: January 26, 2024

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重新探讨胺嵌入的分子框架,探讨蛋白质与蛋白质相互作用的尚未探索的化学空间

Jeong Yeon Yoo1, Yoona Choi1, Heejun Kim1

  • 1Department of Chemistry, Seoul National University, Seoul 08826, Korea (South).

Accounts of chemical research
|October 31, 2024
PubMed
概括

这项研究引入了一种新的基于特权子结构的多样性导向合成 (pDOS) 策略,用于创建针对蛋白质-蛋白质相互作用 (PPI) 的多样化工图书馆. 这种方法产生了独特的胺嵌入式多重环,扩大了以前无法治疗的目标的药物发现可能性.

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