在重症监护病房的重症监护病人的心脏呼吸和昼夜时钟标记器
José Manuel Jiménez-Pastor1,2, Francisco Rodríguez-Cortés1,2, Pablo López-Soto1,2
1Department of Nursing, The Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Spain.
Dental and medical problems
|October 31, 2024
概括
在ICU患者中乱的昼夜节律会影响生命体征. 黑色素和BMAL1水平与心率和血压相关,这表明这些可以监测昼夜功能和患者的结果.
科学领域:
- 生理学 生理学 生理学
- 时间生物学 时间生物学
- 关键护理医学 关键护理医学
背景情况:
- 生物同步节律,特别是昼夜节律,对于睡眠,心率 (HR) 和动脉血压 (BP) 等生理过程至关重要.
- 这些节律的失调与不良健康结果和有机挑战有关.
- 重症监护室 (ICU) 的环境可能会破坏这些关键的生物节奏.
研究的目的:
- 调查ICU环境对危急病患者昼夜钟基因表达和心肺呼吸系统参数的影响.
- 探索时钟基因表达,黑激素水平和生命体征之间的关系.
主要方法:
- 在ICU环境中研究了22名患有心血管疾病的重症患者.
- 使用定量聚合酶链反应 (qPCR) 评估尿液中的黑激素 (MEL) 水平和大脑和肌肉Arnt样蛋白-1 (BMAL1) 的基因表达.
- 持续监测心率 (HR),静脉血压 (SBP),透气血压 (DBP),平均血压 (MBP) 和氧和 (SpO2).
主要成果:
- 尿液MEL和BMAL1与HR和SBP呈现出非线性关系,分别解释了高达50.3%和39.7%的变化.
- MEL还证明了与MBP的非线性关系,解释了其多达31.3%的变化.
- HR和SBP动态与BMAL1基因表达和MEL度有关,MEL也影响MBP.
结论:
- 循环功能矩阵对于重症患者的生命参数动态至关重要.
- 常规心血管参数 (HR,BP) 可能成为ICU中昼夜计时系统功能的重要标志物.
- 这些易于评估的参数对ICU患者的康复,发病率和死亡率具有预后价值.
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