在密码性中风后诊断发生癌症:ARCADIA随机试验的探索性分析
Babak B Navi1, Cenai Zhang1, Benjamin R Miller1
1From the Clinical and Translational Neuroscience Unit (B.B.N., C.Z., A.P., M.B., H.K.), Feil Family Brain and Mind Research Institute and Department of Neurology, Weill Cornell Medicine, New York; Department of Neurology (B.B.N.), Memorial Sloan Kettering Cancer Center, New York, NY; Department of Neurology (B.R.M., C.S.), University of Minnesota, Minneapolis; Division of Hematology and Oncology (M.C.), Department of Medicine, University of Vermont Larner College of Medicine, Burlington; Department of Neurology (S.E.K.), University of Pennsylvania School of Medicine, Philadelphia; Department of Neurology (D.T., W.L.), Department of Epidemiology (W.L.), and Department of Biostatistics (R.K.), University of Washington, Seattle; Department of Biostatistics (J.E.), Medical University of South Carolina, Charleston; Ochsner Neuroscience Institute (R.M.Z., J.T.), Ochsner Health, New Orleans, LA; Department of Neurology and Rehabilitation Medicine (J.P.B.), University of Cincinnati College of Medicine, OH; Sunnybrook Research Institute (D.J.G.), Hurvitz Brain Sciences Program, Sunnybrook Health Sciences Centre, and Division of Neurology (D.J.G.), Department of Medicine, University of Toronto, Ontario, Canada; Department of Neurology (M.B.), Inselspital, Bern University Hospital and University of Bern, Switzerland; and Department of Neurology (M.S.V.E.), Vagelos College of Physicians and Surgeons, and Department of Epidemiology (M.S.V.E.), Mailman School of Public Health, Columbia University, New York, NY.
癌症诊断发生在1.5%的密码性中风患者在一年内. 这项研究强调了密码性中风后监测新癌症诊断的重要性.
科学领域:
- 神经学 神经学
- 在瘤学瘤学.
- 临床试验 临床试验
背景情况:
- 密码性中风,来源不明的中风,影响了许多患者.
- 心房心脏病是密码性中风的已知的危险因素.
- 密码性中风和潜在的癌症之间的潜在联系需要进一步调查.
研究的目的:
- 确定加密性中风患者新癌症诊断的发生率和时间.
- 为了确定在这个患者群体中诊断出的癌症类型.
- 评估中风后一年内癌症的累积发病率.
主要方法:
- 利用了ARCADIA试验的数据,这是一项对患有密码性中风和心房心脏病的患者的前性研究.
- 每3个月对严重不良事件 (包括癌症诊断) 的参与者进行监测.
- 使用卡普兰-梅尔统计数据来估计累积的癌症发病率.
主要成果:
- 在878名参与者中,有13名 (1.5%) 在一年内被诊断出患有癌症.
- 大多数癌症都是固体 (12),包括前列腺,乳腺和胃肠道.
- 观察到一个血液癌症病例 (非霍奇金淋巴瘤). 诊断的中位时间为261天.
结论:
- 在这个密码性中风队列中,癌症诊断的1年累积发病率为2%.
- 这种发病率可能是低估的,因为临床试验的特定人群和排除标准.
- 需要进一步的研究才能充分理解密码性中风和癌症之间的关联.


