在西班牙裔妇女的国际现实世界队列中,采用降低风险的手术
Yanin Chavarri-Guerra1, Ana Ferrigno-Guajardo2, Cynthia Villarreal-Garza3
1Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
JCO global oncology
|October 31, 2024
概括
降低风险的手术 (RRS) 吸收在具有病原性变体 (PVs) 的西班牙裔妇女中是不理想的. 诸如BRCA携带者身份,个人/家庭癌症病史和美国居民身份等因素影响了RRS决策.
科学领域:
- 遗传学和基因组学 在
- 在瘤学瘤学.
- 公共卫生 公共卫生
背景情况:
- 患有乳腺癌 (BC) 和卵巢癌 (OC) 相关基因的致病变体 (PVs) 的女性是癌症风险降低策略的候选人.
- 关于西班牙裔女性接受风险降低手术 (RRS) 的数据有限.
研究的目的:
- 在接受基因癌症风险评估 (GCRA) 的西班牙裔妇女的国际队列中描述RRS吸收率.
- 确定影响该群体RRS吸收的因素.
主要方法:
- 美国和拉丁美洲1,736名西班牙裔妇女的潜在纳入临床癌症基因组学社区研究网络注册表 (1997年7月至2019年12月).
- 通过图表审查和患者报告的后续调查问卷收集数据.
- 平均随访时间为41个月.
主要成果:
- 27.2%接受了降低风险的乳房切除术 (RRM),25.5%进行了降低风险的乳房切除术 (RRSO),10.7%接受了两者.
- 在BRCA载体中,RRM和RRSO的发病率分别为47.6%和56.7%.
- 与较高的RRM吸收相关的因素包括BRCA载体状态 (OR,3.44),个人BC史 (OR,6.22),美国居住 (OR,3.90),年龄≤50 (OR,1.68) 和家族BC史 (OR,1.56). OC基因载体状态 (OR,6.72) 与较高的RRSO吸收有关.
结论:
- 在西班牙裔女性中,RRS的吸收率低于最佳水平.
- 携带PV病毒的人,有个人或家族癌症史的人以及居住在美国的女性更有可能患上RRS.
- 了解影响因素对于制定干预措施以增加适当的RRS吸收至关重要.
更多相关视频
08:26Clinical Application of Single-Surgeon, Three-Port, Laparoscopic Resection for Colorectal Cancer with Natural Orifice Specimen Extraction
Published on: March 24, 2023
372
03:30Author Spotlight: Advancing Pelvic Prolapse Treatment with a Non-Mesh Approach using Laparoscopic Pectopexy
Published on: October 25, 2024
1.4K
相关概念视频
01:23Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
01:12Relative Risk
Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...