消毒剂在低资源环境中的高触摸表面材料上对麻疹病毒无活化的有效性
Ana K Pitol1, Siobhan Richards1, Patrick Mirindi2
1Departments of Vector Biology and Tropical Disease Biology, Centre for Neglected Tropical Diseases, Liverpool School of Tropical Medicine, L3 5QA Liverpool, U.K.
Environmental science & technology
|October 31, 2024
概括
0.05%的化或70%的乙醇有效地在1分钟的接触时间内在各种表面上消毒麻疹病毒 (MPXV). 这些消毒剂具有很高的降低率,对于在资源较少的环境中控制感染至关重要.
科学领域:
- 环境微生物学环境微生物学
- 传染病控制中的传染病控制
- 公共卫生 公共卫生
背景情况:
- 病毒 (MPXV) 构成了严重的公共卫生威胁,需要有效的表面消毒策略.
- 了解各种表面的消毒剂有效性至关重要,特别是在资源有限的环境中.
- 有限的数据存在于MPXV无活化常见的消毒剂在各种表面类型.
研究的目的:
- 在多种表面类型上评估六种常见消毒剂对麻疹病毒 (MPXV) 的消毒有效性.
- 为了确定最佳的消毒剂选择和接触时间MPXV无活化在实际设置.
- 为低资源环境的表面消毒提供基于证据的建议.
主要方法:
- 用MPXV接种的表面载体用六种消毒剂 (0.05%和0.5%的二,70%的乙醇,两种基于QAC的,1.4%的过氧化) 和对照剂进行了处理.
- 在六个常见的表面上进行了消毒:四个无孔 (不钢,玻璃,塑料,乳) 和两个多孔 (陶,木材).
- 在治疗后量化MPXV,接触时间为1分钟,并计算出log10去除值.
主要成果:
- 低酸 (0.05%,0.5%) 和70%乙醇在无孔表面降低了≥99.97%的MPXV,在木材上降低了≥99.40%.
- 基于QAC的消毒剂在无孔表面有效 (≥99.97%无活化),但在木材上效果较差.
- 1.4%的过氧化在所有测试表面的有效性有限;结果因消毒剂和表面类型而异.
结论:
- 建议使用0.05%的低酸或70%的乙醇,在干净的无孔和多孔表面上无效化MPXV,接触时间为1分钟.
- 消毒剂的有效性取决于表面,这凸显了对量身定制的消毒方案的需求.
- 需要进一步研究MPXV菌株的演变,各种应用方法和多孔表面相互作用,以制定全面的消毒指南.
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