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通过红外光谱检测的COVID-19诊断测试的准确性:系统性审查和元分析
Alexandre de Fátima Cobre1, Mariana Millan Fachi2, Karime Zeraik Abdalla Domingues2
1Pharmaceutical Sciences Postgraduate Program, Universidade Federal do Paraná, Curitiba, Brazil; School of Biosciences and Medicine, Faculty of Health and Medical Sciences, University of Surrey, United Kingdom.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
|October 31, 2024
概括
里叶变换红外光谱 (FTIR) 精确检测到COVID-19. 这种快速,低成本的方法显示出高灵敏度和特异性,特别是在接种疫苗的人群中,提供了一个有前途的查工具.
科学领域:
- 分析化学 分析化学
- 医学诊断 医学诊断 医学诊断
- 频谱学是一种光谱学.
背景情况:
- 准确和快速的COVID-19诊断对于公共卫生至关重要.
- 现有的诊断方法在速度,成本或可访问性方面存在局限性.
- 红外光谱学为非侵入性和高效的疾病检测提供了潜力.
研究的目的:
- 系统地审查和综合关于福里埃变换红外光谱 (FTIR) 对于COVID-19诊断的准确性的证据.
- 评估关键准确性参数,包括各种人类样本的灵敏度和特异性.
- 评估FTIR作为SARS-CoV-2感染实际查工具的潜力.
主要方法:
- 系统审查PubMed和Embase发表的研究,截至2023年9月.
- 包括报告灵敏度,特异性和其他诊断准确度指标的研究.
- 使用Meta-Disc软件对精度估计和ROC曲线下的面积 (AUC) 的元分析.
主要成果:
- 包括17项研究,确定了650-1800厘米-1和2300-3900厘米-1的光谱区域对于COVID-19检测至关重要.
- FTIR显示出高的整体灵敏度 (0.912) 和特异性 (0.886).
- 与未接种疫苗 (敏感度0.625,特异性0.667) 相比,接种疫苗的个体 (敏感度0.959,特异性0.884) 的准确性明显更高.
结论:
- FTIR光谱是检测SARS-CoV-2感染在各种生物样本中的一个高度准确的方法.
- 该技术具有成本效益,快速,并且需要最小的样本准备,使其对环境友好.
- FTIR显示出作为可疑COVID-19病例的实际查工具的实施潜力显著,特别是在资源有限的环境中.
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