生物活性介质性二氧化材料辅助癌症免疫疗法
Jiali Liu1, Jiying Liu2, Yaxin Wang3
1Department of Orthopedics, Academy of Orthopedics-Guangdong Province, Orthopedic Hospital of Guangdong Province, Guangdong Provincial Key Laboratory of Bone and Joint Degenerative Diseases, The Third Affiliated Hospital of Southern Medical University, Guangzhou, 510630, China; School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou, Guangdong, 511442, China.
生物活性的中孔 (MS) 材料通过训练免疫细胞来增强癌症免疫疗法. 这些工程MS材料促进强大的抗瘤反应,解决当前治疗的挑战,以获得更好的结果.
科学领域:
- 生物材料科学 生物材料科学
- 免疫学 免疫学 免疫学
- 纳米技术 纳米技术
背景情况:
- 癌症免疫疗法旨在激活免疫细胞对抗瘤,但面临诸如有限的免疫反应等挑战.
- 半孔二氧化 (MS) 材料为药物和免疫调节剂提供可控释放.
- 具有内在免疫调节功能的工程MS材料是改善免疫疗法的关键策略.
研究的目的:
- 审查生物活性MS材料的进展,以增强癌症免疫疗法.
- 突出MS的内在免疫调节功能,超越药物输送.
- 讨论MS辅助免疫疗法的挑战和未来方向.
主要方法:
- 关于癌症免疫治疗中生物活性多发性硬化物质的最新文献的综述.
- 对用于药物和免疫调节剂输送的MS材料特性进行分析.
- 检查瘤微环境和淋巴状组织中MS介导的免疫反应.
主要成果:
- 生物活性MS材料通过诱导免疫细胞死亡和调节免疫细胞活性来协调局部免疫反应.
- 多发性硬化物质促进瘤-免疫细胞相互作用,并招募/激活淋巴状组织中的免疫细胞用于抗瘤疫苗接种.
- 工程MS材料展示了在瘤微环境内按需交付和受控释放的潜力.
结论:
- 生物活性MS材料提供了一个有希望的平台,通过增强抗瘤反应来克服免疫治疗的挑战.
- 具有复杂生物活性和响应能力的MS材料的合理设计对于个性化免疫疗法至关重要.
- 进一步了解物质-生物相互作用将促进MS辅助癌症免疫疗法的开发.
更多相关视频
08:02Isolation of Primary Cancer-Associated Fibroblasts from a Syngeneic Murine Model of Breast Cancer for the Study of Targeted Nanoparticles
Published on: May 14, 2021
09:31Orthotopic Implantation and Peripheral Immune Cell Monitoring in the II-45 Syngeneic Rat Mesothelioma Model
Published on: October 2, 2015
相关概念视频
Tumor Immunotherapy
Targeted Cancer Therapies
There are several types of targeted therapies against...
Cancer Vaccines
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
