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在体外验证通过食品级多单位颗粒系统输送维生素B2的结肠
R E Steinert1, W Sybesma2, R Duss1
1Health, Nutrition & Care (HNC), DSM-Firmenich, Wurmisweg 576, 4303 Kaiseraugst, Switzerland.
Beneficial microbes
|October 31, 2024
概括
这项研究引入了一种新的,食品级的多单位颗粒系统 (MUPS),用于针对性地向结肠输送 riboflavin. 该系统证明在结肠中有效释放,并对肠道微生物群产生积极影响,为功能性食品提供可持续的替代品.
科学领域:
- 食品科学与技术 食品科学与技术
- 胃肠病学 胃肠病学
- 营养科学 营养科学
背景情况:
- 有效成分的向结肠输送在药品中已经确立,但在功能性食品和医疗营养中尚未得到充分研究.
- 新出现的证据强调了结肠营养物质的健康益处,增加了对安全,食品级材料的需求.
- 现有的输送系统往往缺乏可持续性,或者面临着对微塑料的监管审查.
研究的目的:
- 开发和评估一种新的,双层涂层的,食品级的多单元颗粒系统 (MUPS),用于针对性地向结肠输送 riboflavin.
- 在模拟的胃肠道条件下评估MUPS的完整性和释放特征.
- 为了研究含有利博弗拉的MUPS对肠道微生物群的组成和功能的影响.
主要方法:
- 一个双层涂层的MUPS (大约. 730微米) 使用食品级贝 (外层),酸盐 (内层),纤维素 (核心) 和 рибофлавин (活性成分) 制成.
- 在体外评估中使用了USP装置3和TNO肠道模型1和2 (TIM-1,TIM-2) 来模拟消化和发酵.
- 使用TIM-2模型分析了微生物组组成和短链脂肪酸 (SCFA) 生产.
主要成果:
- 在模拟的上部胃肠道条件中,MUPS保持完整性.
- 大约90%的 riboflavin 在模拟的乳腺结肠条件下被释放.
- 蒂姆-2模型表明,含有里波弗拉的MUPS增加了酸盐和丁酸盐的产量,有利于SCFA.
结论:
- 开发的食品级MUPS适合向肠道输送 riboflavin,证明控制释放和肠道微生物群的积极调节.
- 这种配方为功能性食品和医疗营养应用中的微塑料涂层提供了一个可持续和环保的替代方案.
- 人类临床试验的进一步验证是有必要的,以确认这种维生素充满的MUPS的疗效.
相关概念视频
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