在呼吸变化期间测量在额头上的血液动力学和血管氧化量:SPA-fNIRS研究
Sabino Guglielmini1, Elena Wiggli2, Felix Scholkmann3
1Biomedical Optics Research Laboratory, Department of Neonatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland; Biomedical Family Larsson-Rosenquist Foundation Center for Neurodevelopment, Growth and Nutrition of the Newborn, Department of Neonatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
呼吸通过改变二氧化碳水平,显著影响大脑血流. 这项研究表明,大脑和脑外组织的氧化和前额血动力学都受到呼吸变化的影响.
科学领域:
- 生理学 生理学 生理学
- 神经成像是一种神经成像.
背景情况:
- 大脑血流 (CBF) 是通过呼吸活动调节的,主要是由于动脉二氧化碳 (CO2) 水平的波动.
- 了解呼吸对大脑和脑外血动力学的影响对于准确的功能近红外光谱学 (fNIRS) 研究至关重要.
研究的目的:
- 研究由呼吸机动诱导的动脉二氧化碳度变化如何影响大脑和脑外额头组织中的氧化和血液动力学.
- 探索呼吸挑战与组织氧化和大脑及其外层的血液流动之间的关系.
主要方法:
- 系统生理增强功能近红外光谱学 (SPA-fNIRS) 在20名健康参与者中使用.
- 参与者接受了两种不同的呼吸任务:屏息和高通风.
主要成果:
- 呼吸变化显然影响了脑外和脑额头组织层中的血液动力学和氧化.
- 观察到的效应在喘息和高通风任务之间有明显的差异.
结论:
- 确定了脑外血管反应 (ECVR),与已确定的脑血管反应 (CVR) 平行运行.
- CVR和ECVR都是关键因素,必须在fNIRS神经成像研究中考虑到呼吸系统变异的发生.
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