丸激素对大脑结构变化速率的因果影响:一项性别分层的门德尔随机化研究
Xin Lian1, Yaqi Bai2, Pengyang Du3
1Department of Obstetrics and Gynecology, People's Hospital of Linyi County, Yuncheng Central Hospital of Shanxi Medical University, 1125 Fuxi Street, Yuncheng 044100, China.
The Journal of steroid biochemistry and molecular biology
|October 31, 2024
概括
水平因果关系地影响大脑结构的变化,影响不同性别的白质,表面积和海马. 性激素结合型全球蛋白对男性和女性的大脑结构的影响不同.
科学领域:
- 神经内分泌学神经内分泌学
- 神经成像遗传学 神经成像遗传学
背景情况:
- 对大脑结构的影响已知,但特定区域和因果关系尚不清楚.
- 了解这些关系对于理解大脑发育和衰老至关重要.
研究的目的:
- 通过使用孟德尔随机化来研究丸激素水平和纵向大脑结构变化之间的因果关系.
- 为了确定受和相关激素影响的特定大脑区域.
主要方法:
- 利用孟德尔的随机化与全基因组关联研究 (GWAS) 来自欧洲参与者的水平数据 (N=425,097).
- 采用了来自ENIGMA联盟 (N=15,640) 的纵向大脑结构变化的GWAS数据.
- 应用逆方差加权 (IVW),MR Egger和加权中位数方法,以获得可靠的因果推断.
主要成果:
- 总和生物可用和女性大脑白质 (WM) 和表面积的年龄独立变化之间的正相关性.
- 性激素结合环球蛋白 (SHBG) 和依赖年龄的皮质灰质 (GM) 变化在男性之间存在负相关性.
- 在男性中,生物可用丸激素与白色球体的四级年龄依赖变化有负相关;在男性中,雌激醇和SHBG与四级年龄依赖的总大脑变化有负相关.
- 总和线性依赖年龄的海马体变化在两性之间存在正相关性.
结论:
- 水平对大脑结构变化产生因果作用,有性别特定的区域影响.
- 这些发现突显了大脑-腺轴在大脑结构中的作用,特别是在女性大脑发育中的作用.
- 建立了性激素和随着时间的推移动态的大脑结构变化之间的因果关系.
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