2021年肝癌:全球疾病负担研究
En Ying Tan1, Pojsakorn Danpanichkul2, Jie Ning Yong3
1Division of Gastroenterology and Hepatology, Department of Medicine, National University Health System, Singapore.
Journal of hepatology
|October 31, 2024
概括
全球肝癌病例和死亡人数正在上升,尽管年龄调整率下降. 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是一个日益关注的问题,而病毒性肝炎的发病率正在下降. 迫切需要采取行动来应对这些趋势.
科学领域:
- 肝病学和胃肠道学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 全球肝癌流行病学正在由于代谢性疾病,酒精消费和病毒性肝炎管理而发生转变.
- 肝癌的治疗和负担在不同人群中存在持续的差异.
- 肝癌负担和促成因素的趋势需要持续评估.
研究的目的:
- 评估2010年至2021年肝癌发病率和死亡率的全球和区域时间趋势.
- 分析各种病因对肝癌负担的贡献.
- 确定肝癌中不断变化的风险因素和差异.
主要方法:
- 利用了2021年全球疾病负担研究的方法框架.
- 分析了肝癌发病率和死亡率的全球和区域时间趋势.
- 量化了不同肝病病因的贡献.
主要成果:
- 在2021年,全球记录了超过529,000例肝癌病例和483,000例死亡.
- 2010年至2021年间,全球肝癌病例和死亡人数分别增加了26%和25%.
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 呈现年龄标准化率的上升,而不是HBV和HCV的下降率,以及与酒精有关的肝癌的稳定率.
结论:
- 肝癌病例和死亡人数的绝对数量正在增加,尽管因人口增长和老龄化而导致的年龄调整率下降.
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是肝癌发病率和死亡率的新兴驱动因素.
- 继续努力对抗病毒性肝炎,减少酒精消费和解决MASLD风险因素至关重要,以减轻肝癌负担.
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