超同胞蛋白血症与MASLD有关
Carlo De Matteis1, Lucilla Crudele1, Ersilia Di Buduo1
1Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.
European journal of internal medicine
|October 31, 2024
概括
高水平的同类氨酸 (Hcy) 与代谢相关的脂肪性肝病 (MASLD) 有关. 这项研究在MASLD患者中发现过高血糖蛋白 (HHcy),这与葡萄糖和脂质状况差以及维生素D水平低有关.
科学领域:
- 生物化学 生物化学
- 肝病学 肝病学是一种肝病学.
- 心血管医学 心血管医学
背景情况:
- 在心血管疾病 (CVD),糖尿病和与代谢相关的脂肪性肝病 (MASLD) 中观察到高水平的同类氨酸 (Hcy).
- 了解Hcy在MASLD中的病因作用对于患者管理至关重要.
研究的目的:
- 调查同类氨酸 (Hcy) 水平与代谢相关的脂肪性肝病 (MASLD) 之间的关联.
- 分析患有高homocysteinemia (HHcy) 的门诊患者的临床和生化特征.
主要方法:
- 追溯分析901名门诊患者的物理和生化数据.
- 腹部和动脉超声检查,以评估肝脏肥胖症,动脉内心介质厚度 (IMT) 和动脉样硬化斑块.
- 统计分析以确定Hcy,MASLD和其他健康指标之间的关系.
主要成果:
- 16%的患者患有高血型囊血症 (HHcy),与葡萄糖代谢受损,脂质状况变化,维生素D低,心血管风险增加有关.
- 在Hcy和MASLD (OR=3.6) 之间发现了显著的关联,在调整混因子 (OR=3.2) 后仍然存在.
- MASLD患者表现出更高的Hcy水平和Hcy,腰围,HDL-c和维生素D之间的相关性.
结论:
- 高血糖血症 (HHcy) 在MASLD患者中很普遍,并且与较低的维生素D和不良的葡萄糖/脂质概况有关.
- 监测Hcy水平可能有助于管理患有MASLD和相关并发症风险的患者.
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