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通过调整水友性和脂友性来改善Zr(IV) 纳米的细胞内化

Shunfu Du^1,2, Jinxiao Lyu³, Zhenfeng Yu⁴

¹State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, 350002, PR China.

Angewandte Chemie (International ed. in English)

|October 31, 2024

概括

研究人员开发了水溶性基金属有机 (MOCs),具有鲜红色光. 基基改造显著提高了细胞吸收,使这些纳米成为生物应用的有望应用.

科学领域:

材料科学材料科学材料科学
纳米技术纳米技术
化学化学化学

背景情况:

纳米级分子材料提供精确的化学结构和统一性.
基于的金属有机 (MOCs) 在催化和分离中表现出稳定性和潜力.
较差的水溶性限制了当前MOCs的生物医学应用.

研究的目的:

为了提高水溶性,并为基于的MOC引入光.
为了改善MOCs的细胞吸收,用于生物医学应用.
探索在生物环境中修改MOC的潜力.

主要方法:

用 (Ruthenium) 复合物进行联体装饰,以提高溶解度并增加光.
基修饰环白二烯环,以增强细胞透.
调查细胞吸收机制,包括由actin和dynamin介导的内细胞分裂.

主要成果:

修改后的MOC表现出更好的水溶性和明亮的红色光,具有很大的斯托克斯转移 (180nm).
基修饰导致细胞吸收增加了100倍.
增强的纳米体显示出生物应用的巨大潜力.

结论:

((II) 复杂的装饰和丁修饰是克服MOC限制的有效策略.
这些修改后的MOC对各种生物医学应用非常有前途,因为它们提高了溶解度,光和细胞吸收.
这些纳米的易于修改,为纳米医学的进一步发展开辟了道路.

关键词:

细胞吸收细胞吸收.协调子协调子活细胞成像技术使用.锡尔科尼 (Zirconium) 是一种有机物.

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