个性化生物陶移植用于骨面骨再生
Ana Beatriz G de Carvalho1,2, Maedeh Rahimnejad1, Rodrigo L M S Oliveira3
1Department of Cariology, Restorative Sciences and Endodontics, School of Dentistry, University of Michigan, Ann Arbor, MI, USA.
International journal of oral science
|November 1, 2024
概括
3D打印的生物陶支架为关面骨缺陷重建提供了一个有希望的替代方案. 这些个性化的合成移植支持新的骨生长,并且可以随着时间的推移降解,解决当前方法的局限性.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 添加剂制造 添加剂制造 添加剂制造
- 头骨和面部外科手术
背景情况:
- 头骨和面部骨缺陷的重建具有挑战性,因为自身移植具有显著的缺点.
- 人工移植正在探索中,增材制造 (AM) 显示出相当大的临床潜力.
- 机械增强能够实现个性化,三维 (3D) 生物材料结构,可以指导骨再生.
研究的目的:
- 审查3D打印生物陶移植和支架的关键进展,以进行个性化关面骨重建.
- 讨论临床相关方面,包括生物材料,脚手架特性和制造工作流程.
- 检查体外模型和信号通路在评估细胞对生物陶的反应中的作用.
主要方法:
- 关于3D打印生物陶移植的文献综述,用于骨和面部应用.
- 讨论基于陶的生物材料,脚手架的宏观/微观特征,以及基于挤出材料的AM.
- 对体外模型和与生物陶支架相关的细胞信号通路的分析.
主要成果:
- 3D打印生物陶支架可以设计为个性化几何形状和受控的降解.
- 这些结构支持细胞迁移,增殖,骨质生成和血管生成.
- 试验室研究突出了影响生物陶细胞行为的特定信号通路.
结论:
- 通过3D打印制造的个性化生物陶移植,代表了骨面骨再生的重大进步.
- 这些合成移植提供了一个可行的替代品自生移植,具有临床翻译的潜力.
- 对材料优化和体外/体内验证的进一步研究对于广泛采用至关重要.
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